What causes systemic lupus erythematosus?

Written by Li Jing

Rheumatology

Updated on September 05, 2024

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Firstly, systemic lupus erythematosus belongs to autoimmune diseases and is a multisystemic autoimmune disorder. It is a chronic disease that cannot be cured. It can only be managed through medication to control the progression of the disease, prevent relapses, delay damage to other organs, and prevent complications. This is the overall principle of treatment. Its cause is currently unclear. It is only related to factors such as environmental pollution, viral infections, genetics, and hormones, according to expert research. However, there is no specific definitive cause identified.

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Written by Li Jing

Rheumatology

1min 16sec

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What to do about hair loss from systemic lupus erythematosus?

Systemic lupus erythematosus is a multi-system, multi-damage autoimmune disease, primarily manifesting in the skin and mucous membranes. Some individuals may also experience low-grade fever and hair loss, even severe hair loss. If treatment has already commenced and hair loss continues during the treatment process, it is necessary to consider whether the medication dosage is insufficient and to consider adjusting the medication dosage. If medication has been discontinued and severe hair loss reoccurs, the first consideration should be whether there is a recurrence of active disease, necessitating a visit to the hospital for tests including a complete blood count, erythrocyte sedimentation rate, C-reactive protein, complement levels, and autoimmune antibodies to comprehensively assess whether the disease has relapsed. If the disease has relapsed, it is necessary to reintroduce steroids, adjust medication dosages, and combine the use of hydroxychloroquine to control the disease. (Specific medications should be used under the guidance of a physician.)

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Written by Li Jing

Rheumatology

1min 8sec

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Systemic Lupus Erythematosus Test Items

First, if there are symptoms such as facial erythema, butterfly rash, joint pain, hair loss, or even stillbirth or miscarriage, systemic lupus erythematosus should be suspected. For systemic lupus erythematosus, related medical tests are necessary, including complete blood count, urinalysis, erythrocyte sedimentation rate, C-reactive protein, 13 autoantibody tests, and anticardiolipin antibodies. These are the primary and most basic tests, specifically the 13 autoantibody tests. If the diagnosis is confirmed based on these tests, further assessments such as heart evaluation, chest CT need to be perfected. When necessary, 24-hour urine protein quantitation and kidney biopsy should be performed to assess the damage to the kidneys and the severity of the condition, mainly influencing the subsequent treatment plan.

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Written by Yang Ya Meng

Rheumatology

58sec

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What causes systemic lupus erythematosus?

Systemic lupus erythematosus mainly has four major causes: The first is related to the environment. Long-term exposure to sunlight, or living in a humid environment, may trigger the onset of systemic lupus erythematosus. Secondly, there is a certain genetic predisposition to systemic lupus erythematosus. If the parents have systemic lupus erythematosus, the probability of their offspring developing the disease is higher. Thirdly, systemic lupus erythematosus is also related to estrogen, which is why, clinically, lupus is more commonly seen in women of childbearing age and less often in men. Systemic lupus erythematosus is also associated with some specific infections, such as bacterial or viral infections, which may trigger a lupus flare-up.

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Written by Li Jing

Rheumatology

1min

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Systemic Lupus Erythematosus Symptom Chart

Firstly, systemic lupus erythematosus is a multi-system, multi-organ autoimmune disease that cannot be cured but can only be controlled with medication to slow the progression of the disease and prevent complications. Clinical manifestations are diverse, with most early symptoms typically being atypical, and sometimes not presenting any discomfort at all. Some individuals may experience acute onset, which can include high fever, progressive decline in platelets, and even progressive anemia, all characteristic of the acute phase. Other common symptoms include fever, skin erythema, and even ischemia of the extremities. Some people may experience joint pain, mainly in the finger joints and knee joints, as well as swelling of the lower limbs, chest tightness, and decreased exercise tolerance, which are more typical manifestations.

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Written by Li Jing

Rheumatology

1min 1sec

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Can systemic lupus erythematosus be cured completely?

Firstly, systemic lupus erythematosus is a chronic autoimmune disease that causes damage to multiple systems. Its occurrence is associated with factors such as genetics, environmental pollution, infections, and hormone levels. As an autoimmune disease, it cannot be completely cured. Treatment involves using medications to control symptoms, delay the onset of complications, reduce disability rates, and improve quality of life. This represents the comprehensive goals of its treatment. The first choice of treatment is corticosteroids. Once diagnosed with systemic lupus erythematosus, it is essential to conduct thorough examinations to assess the activity of the disease and the organs involved. Based on the activity of the disease and the organs affected, the dosage of treatment may vary.