What to do if systemic lupus erythematosus causes a fever?

Written by Yang Ya Meng
Rheumatology
Updated on March 09, 2025
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Patients with systemic lupus erythematosus (SLE) who develop a fever first need to discern whether the fever is due to immune-related fever caused by the activity of the disease or an infectious fever due to weakened immunity from long-term use of steroids and immunosuppressants. If the fever is caused by lupus activity, then it is necessary to increase the dosage of corticosteroids in treatment. If the fever is due to an infection, a full course of anti-infection treatment is needed. The anti-infection regimen may even need to include treatments with antibacterial, antifungal, and antiviral medications. (Please follow professional medical advice for medication use, and do not self-medicate.)

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Can people with systemic lupus erythematosus have children?

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Systemic lupus erythematosus is a multi-system, multi-damage autoimmune disease, primarily manifesting in the skin and mucous membranes. Some individuals may also experience low-grade fever and hair loss, even severe hair loss. If treatment has already commenced and hair loss continues during the treatment process, it is necessary to consider whether the medication dosage is insufficient and to consider adjusting the medication dosage. If medication has been discontinued and severe hair loss reoccurs, the first consideration should be whether there is a recurrence of active disease, necessitating a visit to the hospital for tests including a complete blood count, erythrocyte sedimentation rate, C-reactive protein, complement levels, and autoimmune antibodies to comprehensively assess whether the disease has relapsed. If the disease has relapsed, it is necessary to reintroduce steroids, adjust medication dosages, and combine the use of hydroxychloroquine to control the disease. (Specific medications should be used under the guidance of a physician.)

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What to do if systemic lupus erythematosus causes a fever?

Patients with systemic lupus erythematosus (SLE) who develop a fever first need to discern whether the fever is due to immune-related fever caused by the activity of the disease or an infectious fever due to weakened immunity from long-term use of steroids and immunosuppressants. If the fever is caused by lupus activity, then it is necessary to increase the dosage of corticosteroids in treatment. If the fever is due to an infection, a full course of anti-infection treatment is needed. The anti-infection regimen may even need to include treatments with antibacterial, antifungal, and antiviral medications. (Please follow professional medical advice for medication use, and do not self-medicate.)