Principles of treatment for hyperkalemia

Written by Zhao Xin Lan
Endocrinology
Updated on December 10, 2024
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First, to counteract the cardiac inhibitory effects of potassium, calcium salts can be injected, and sodium bicarbonate can be used to alkalinize the blood. Then, an infusion of hypertonic glucose and insulin can be administered to promote the internal movement of potassium ions. Secondly, to promote the excretion of potassium, diuretics can be used. The second method involves the use of cation exchange resins and sorbitol. The third method employs dialysis therapy, which can include both hemodialysis and peritoneal dialysis. The fourth method is to reduce the sources of potassium, stop a high potassium diet or the use of potassium-containing drugs. In cases of severe hyperkalemia, where there is a life-threatening emergency, urgent measures should be taken, primarily the intravenous administration of calcium ion antagonists to counteract the cardiac toxicity of potassium. In cases of severe arrhythmias or even cardiac arrest, emergency installation of a pacemaker or defibrillation can be carried out, and respiratory muscle paralysis may require ventilatory support. (Medication use should be under the guidance of a doctor)

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Written by Tang Zhuo
Endocrinology
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Hyperkalemia is seen in which diseases?

When serum potassium levels exceed 5.5 millimoles per liter, it is referred to as hyperkalemia. Elevated serum potassium does not reflect an overall increase in body potassium, but due to limitations in testing methods, the clinical diagnosis of hyperkalemia still relies on combining serum potassium levels with electrocardiogram history. The causes of hyperkalemia are complex and commonly include: First, decreased renal potassium excretion, seen in acute kidney failure or insufficiency in adrenal cortical hormone synthesis and secretion, or long-term use of potassium-sparing diuretics; Second, shifts of potassium from inside the cells, often due to hemolysis, tissue damage, large-scale necrosis of tumors and inflammatory cells, shock, burns, excessive muscle contractions, acidosis, or injection of hypertonic saline or mannitol, which causes dehydration inside cells and leads to potassium leakage, resulting in hyperkalemia; Third, excessive intake of potassium-containing medications, such as high doses of potassium penicillin; Fourth, transfusion of stored blood can lead to hyperkalemia; Fifth, digitalis poisoning can cause hyperkalemia.

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Written by Chen Li Ping
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Can hyperkalemia be cured?

The main focus is on the cause of hyperkalemia. If hyperkalemia is due to consuming foods rich in potassium, administration of potassium-containing solutions, transfusion of stored blood, use of potassium-sparing diuretics like spironolactone, or prolonged venipuncture causing severe shaking of the blood sample during transport, addressing these causes can prevent the occurrence of hyperkalemia. If hyperkalemia is caused by certain diseases, such as renal failure or adrenal insufficiency, active treatment of the underlying disease is required. If the renal failure is acute, recovery of kidney function might prevent the recurrence of hyperkalemia. However, if there is chronic renal insufficiency, there tends to be a higher recurrence rate of hyperkalemia. Therefore, whether hyperkalemia can be cured largely depends on identifying the underlying cause.

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Written by Zhao Xin Lan
Endocrinology
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How should hyperkalemia be managed?

First, it is necessary to assess the severity of the hyperkalemia, whether it is mild, moderate, or severe. For mild hyperkalemia, it can be managed by taking oral diuretics or intravenous infusion of glucose with insulin, which can normalize the potassium level. In cases of severe hyperkalemia, where blood potassium exceeds 7.5 mmol/L, there is a risk of causing cardiac arrest. Emergency measures to promote potassium excretion are required, such as hemodialysis or peritoneal dialysis. It is also necessary to counteract the myocardial depressive effects of potassium, which can be managed with the injection of calcium gluconate, along with the intravenous infusion of hypertonic glucose and insulin. (The use of medications should be conducted under the guidance of a doctor.)

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Written by Luo Han Ying
Endocrinology
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What should not be eaten with hyperkalemia?

Potassium is an important element in human blood. Typically, the electrolytes we measure in blood tests include sodium, potassium, chloride, and calcium. Both low and high levels of potassium can have adverse effects on the body, especially hyperkalemia, which can cause sudden cardiac arrest and is considered dangerous in clinical settings. Patients with normal kidney function are less likely to develop hyperkalemia, which is more commonly seen in those who may have consumed Chinese herbal medicines containing high amounts of potassium for a long time. In patients with renal insufficiency, due to impaired kidney excretory function, hyperkalemia occurs more easily. Patients with hyperkalemia should generally avoid ACE inhibitors and ARB medications. For example, drugs like ACE inhibitors and spironolactone can further exacerbate hyperkalemia, so these types of medications are definitely not advisable. (The use of medications should be under the guidance of a professional doctor.)

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Written by Luo Han Ying
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Why does hyperkalemia cause muscle weakness?

The muscles that govern movement in our body are striated muscles, and each muscle cell in striated muscles has many receptors, which we can think of as a signal receiving and transmitting station. When we need to move, the brain nerves will send a signal to this station, which then controls muscle movement. A very important ion in muscle movement is the calcium ion. There is a receptor for calcium ions on our muscle cells, and it is related to the concentration of blood potassium. When the concentration of blood potassium is too low, a condition known as hypokalemia, or too high, known as hyperkalemia, the calcium ion receptor will be inhibited. At this point, our muscles will exhibit symptoms of muscle weakness.