Principles of treatment for hyperkalemia

Written by Zhao Xin Lan
Endocrinology
Updated on December 10, 2024
00:00
00:00

First, to counteract the cardiac inhibitory effects of potassium, calcium salts can be injected, and sodium bicarbonate can be used to alkalinize the blood. Then, an infusion of hypertonic glucose and insulin can be administered to promote the internal movement of potassium ions. Secondly, to promote the excretion of potassium, diuretics can be used. The second method involves the use of cation exchange resins and sorbitol. The third method employs dialysis therapy, which can include both hemodialysis and peritoneal dialysis. The fourth method is to reduce the sources of potassium, stop a high potassium diet or the use of potassium-containing drugs. In cases of severe hyperkalemia, where there is a life-threatening emergency, urgent measures should be taken, primarily the intravenous administration of calcium ion antagonists to counteract the cardiac toxicity of potassium. In cases of severe arrhythmias or even cardiac arrest, emergency installation of a pacemaker or defibrillation can be carried out, and respiratory muscle paralysis may require ventilatory support. (Medication use should be under the guidance of a doctor)

Other Voices

doctor image
home-news-image
Written by Zhao Xin Lan
Endocrinology
46sec home-news-image

Clinical manifestations of hyperkalemia

The clinical manifestations of hyperkalemia are not specific. Early symptoms often include numbness in the limbs, sensory abnormalities, extreme fatigue, and muscle pain. In severe cases, there can be difficulties in swallowing, speaking, and breathing, paralysis of the limbs, and tendon reflexes may disappear. The central nervous system may show signs of restlessness, fainting, and confusion. Some may experience a slow heart rate, ventricular fibrillation, and in the most severe cases, it can lead to cardiac arrest. Other symptoms may include nausea, vomiting, diarrhea, and other gastrointestinal symptoms.

doctor image
home-news-image
Written by Wei Shi Liang
Intensive Care Unit
57sec home-news-image

Hyperkalemia can be seen in which diseases?

Hyperkalemia is a condition where the serum potassium concentration exceeds 5.5 millimoles per liter. Common causes include excessive intake of potassium, such as high-dose potassium penicillin intravenous infusion, ingestion of potassium-containing medications, or transfusion of large amounts of stored blood, all of which can lead to hyperkalemia. Additionally, patients with renal failure who experience oliguria or anuria may have reduced potassium excretion. In such cases, inappropriate potassium supplementation or the use of potassium-sparing diuretics can lead to severe hyperkalemia. Lastly, the movement of potassium from inside the cells—during metabolic acidosis and respiratory acidosis—causes ion exchange, leading to hydrogen ions entering the cells while potassium ions leak out, resulting in hyperkalemia.

doctor image
home-news-image
Written by Yang Li
Endocrinology
51sec home-news-image

What medication is used for hyperkalemia?

Hyperkalemia is primarily treated by promoting diuresis to enhance the elimination of potassium, while calcium gluconate can also be administered intravenously to counteract the inhibitory effects of potassium on the heart. Additionally, concentrated glucose with insulin can be used to shift excess potassium ions from the blood. Sodium bicarbonate can also be used to alkalinize the blood's pH to help reduce potassium levels. All these treatments must be conducted safely. In cases of severe hyperkalemia, dialysis may be necessary. If arrhythmias, bradycardia, or myocardial depression occur, the installation of a temporary pacemaker, along with hemodialysis, may be required. (Medication should be administered under the guidance of a physician.)

doctor image
home-news-image
Written by Chen Li Ping
Endocrinology
57sec home-news-image

Can hyperkalemia be cured?

The main focus is on the cause of hyperkalemia. If hyperkalemia is due to consuming foods rich in potassium, administration of potassium-containing solutions, transfusion of stored blood, use of potassium-sparing diuretics like spironolactone, or prolonged venipuncture causing severe shaking of the blood sample during transport, addressing these causes can prevent the occurrence of hyperkalemia. If hyperkalemia is caused by certain diseases, such as renal failure or adrenal insufficiency, active treatment of the underlying disease is required. If the renal failure is acute, recovery of kidney function might prevent the recurrence of hyperkalemia. However, if there is chronic renal insufficiency, there tends to be a higher recurrence rate of hyperkalemia. Therefore, whether hyperkalemia can be cured largely depends on identifying the underlying cause.

doctor image
home-news-image
Written by Wei Shi Liang
Intensive Care Unit
1min 5sec home-news-image

Treatment of Hyperkalemia with Drugs

Hyperkalemia primarily affects the conduction of the heart and muscle nerves, with typical clinical manifestations including severe bradycardia, atrioventricular block, and even sinus arrest. Once hyperkalemia occurs clinically, immediate treatment should be administered. The first approach to treatment is promoting the excretion of potassium, using furosemide or other diuretics to increase renal potassium excretion, and taking a small dose of sodium polystyrene sulfonate orally to eliminate potassium. For life-threatening severe hyperkalemia, if serum potassium is greater than 6.5 mmol/L, hemodialysis treatment is necessary. The second aspect involves shifting potassium into cells, using calcium to alter cell excitability, which can protect the heart from the damage to the conduction system caused by hyperkalemia. Additionally, using glucose with insulin and administering sodium bicarbonate can be effective. It is important to note that all the above medications should be used under the guidance of a doctor.