Causes of Malignant Lymphoma

Written by Liu Liang
Oncology
Updated on November 30, 2024
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The causes of malignant lymphoma are the result of multiple factors. First, it is associated with infections by bacteria or viruses, such as the well-documented chronic infection with Helicobacter pylori, which is closely related to the occurrence of lymphoma associated with the gastric mucosa. Second, immunodeficiency conditions, like in AIDS patients or those who have been taking immunosuppressive drugs for a long period, have a higher likelihood of developing malignant lymphoma compared to the general population. Third, chemical or physical factors, such as environmental carcinogens and electromagnetic radiation, can also lead to malignant lymphoma. Other factors, such as long-term use of certain drugs like phenytoin or pseudoephedrine, and a genetic predisposition, can also be causes of malignant lymphoma.

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Written by Zhou Chen
Oncology
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What to check for malignant lymphoma?

The examination of lymphoma first requires routine blood tests and blood smears. When aggressive lymphoma invades the bone marrow, anemia, decreased white blood cells, and platelets may occur, and lymphoma cells can appear in peripheral blood; therefore, bone marrow smears and biopsies are necessary. Additionally, blood biochemistry is important, as an increase in lactate dehydrogenase is associated with tumor burden and is an indicator of poor prognosis. Furthermore, Hodgkin's lymphoma may involve the central nervous system, so patients with symptoms of central nervous system involvement need to undergo cerebrospinal fluid examination. The most important aspect of lymphoma is the histopathological examination. Based on the histopathological examination, the pathological staging is determined, and genetic rearrangement can also be performed.

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Written by Liu Liang
Oncology
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early symptoms of Hodgkin's lymphoma

Malignant lymphoma refers to a type of malignant tumor that originates in the lymph nodes or extranodal organs or tissues. Therefore, Hodgkin's lymphoma is a type of lymphoma. Its early symptoms mainly start with the enlargement of superficial lymph nodes throughout the body, with 90% of Hodgkin's lymphoma patients presenting with enlargement of superficial lymph nodes as an early symptom when they seek medical advice. The most common superficial lymph nodes are those above the collarbone and in the neck, but enlargement can also occur in the axillary and inguinal lymph nodes, which are also some of the more common early clinical manifestations seen in practice.

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Written by Liu Liang
Oncology
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The pattern of fever in lymphoma

Fever symptoms are quite common in patients with lymphoma, which we refer to as B symptoms. The pattern of their fevers is primarily low-grade, occurring more frequently in the afternoon or evening. Unlike ordinary bacterial infections, fevers in these patients do not respond well to anti-inflammatory drugs, but they do respond better to steroid treatment for reducing fever. However, if the lymphoma is not under control, their fever will repeatedly recur. Corresponding cooling treatments can reduce the temperature, but the fever will reoccur repeatedly. Only when the lymphoma and tumor are under control will the fever symptoms start to improve.

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Written by Peng Li Bo
Oncology
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Is lymphoma hereditary?

Lymphoma is generally not hereditary, as it is not a genetic disease. However, I must mention that most neoplastic diseases do have some hereditary factors to some extent. The reason for this is that the cause of lymphoma is currently unclear, and it may be related to genetic mutations, which raises the issue of heredity. Another point is that heredity often refers to transmission among direct relatives. This means there could be a problem in that you might share similar environments and lifestyles, including diet. If there are factors in your diet or living environment that could trigger lymphoma, and you are both exposed to these factors, then your probability of developing lymphoma could indeed be higher than in patients without a family history, leading to such a concern.

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Written by Liu Liang
Oncology
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Causes of Malignant Lymphoma

The causes of malignant lymphoma are the result of multiple factors. First, it is associated with infections by bacteria or viruses, such as the well-documented chronic infection with Helicobacter pylori, which is closely related to the occurrence of lymphoma associated with the gastric mucosa. Second, immunodeficiency conditions, like in AIDS patients or those who have been taking immunosuppressive drugs for a long period, have a higher likelihood of developing malignant lymphoma compared to the general population. Third, chemical or physical factors, such as environmental carcinogens and electromagnetic radiation, can also lead to malignant lymphoma. Other factors, such as long-term use of certain drugs like phenytoin or pseudoephedrine, and a genetic predisposition, can also be causes of malignant lymphoma.