Is lymphoma hereditary?

Written by Peng Li Bo
Oncology
Updated on January 17, 2025
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Lymphoma is generally not hereditary, as it is not a genetic disease. However, I must mention that most neoplastic diseases do have some hereditary factors to some extent. The reason for this is that the cause of lymphoma is currently unclear, and it may be related to genetic mutations, which raises the issue of heredity. Another point is that heredity often refers to transmission among direct relatives. This means there could be a problem in that you might share similar environments and lifestyles, including diet. If there are factors in your diet or living environment that could trigger lymphoma, and you are both exposed to these factors, then your probability of developing lymphoma could indeed be higher than in patients without a family history, leading to such a concern.

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What to check for malignant lymphoma?

The examination of lymphoma first requires routine blood tests and blood smears. When aggressive lymphoma invades the bone marrow, anemia, decreased white blood cells, and platelets may occur, and lymphoma cells can appear in peripheral blood; therefore, bone marrow smears and biopsies are necessary. Additionally, blood biochemistry is important, as an increase in lactate dehydrogenase is associated with tumor burden and is an indicator of poor prognosis. Furthermore, Hodgkin's lymphoma may involve the central nervous system, so patients with symptoms of central nervous system involvement need to undergo cerebrospinal fluid examination. The most important aspect of lymphoma is the histopathological examination. Based on the histopathological examination, the pathological staging is determined, and genetic rearrangement can also be performed.

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How to check for lymphoma?

Patients with lymphoma generally present with painless enlargement of superficial lymph nodes as their initial symptom, most commonly in areas such as the neck, above the collarbone, and the groin. For diagnostic purposes, it is best, if possible, to conduct a whole-body PADCT scan as this helps in the staging of lymphoma at the initial visit. A definitive diagnosis requires the complete excisional biopsy of the affected superficial lymph node, followed by a pathological examination. An excisional biopsy is a method for confirming the diagnosis of lymphoma.

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Early symptoms of lymphoma

The early symptoms of lymphoma patients are primarily due to its predilection for lymph nodes, with the majority of cases initially presenting with swollen lymph nodes in the neck or collarbone area. These lymph nodes usually enlarge progressively without pain, which is the most common early clinical symptom. However, some specific types of lymphoma, such as nasal NKT lymphoma, present with localized symptoms like nasal congestion, nosebleeds, or a runny nose. There are also lymphomas originating in the stomach, part of the digestive tract, whose symptoms include upper abdominal pain, nausea, or vomiting. Furthermore, some lymphomas originate in the skin, manifesting as skin nodules. Therefore, depending on the site of occurrence, the symptoms can vary, but the enlargement of superficial lymph nodes remains the primary clinical manifestation in most cases.

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Does lymphoma infect family members?

Lymphoma and other malignant tumors, such as lung cancer, breast cancer, intestinal cancer, liver cancer, etc., are all non-contagious. Therefore, even if you live with your family every day, you do not have to worry about transmitting malignant tumors to your family members; they are not contagious. When we refer to contagious diseases, we call them infectious diseases, common ones include tuberculosis, hepatitis B, hepatitis C, H1N1, etc. These are contagious diseases, but malignant tumors are not contagious and will not be spread to family members.

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How is Hodgkin's lymphoma treated?

The treatment of Hodgkin's lymphoma is based on various factors including the stage of the disease as well as the general condition of the patient, among other comprehensive considerations. For patients with early stage Hodgkin's lymphoma, commonly referred to as localized Hodgkin's lymphoma, the treatment principle is a combination of chemotherapy and radiotherapy. A rational comprehensive treatment can achieve a five-year survival rate of 80% to 90%. For advanced-stage patients, such as those with stage IV Hodgkin's lymphoma, the treatment primarily consists of systemic chemotherapy. Therefore, the choice of a specific treatment plan must also consider a variety of factors based on the patient's overall condition.