Hand, foot, and mouth disease is an acute febrile illness caused by an intestinal virus infection. It is primarily characterized by vesicles or papulovesicular rashes on the hands, feet, mouth, and buttocks. There are over 20 types of intestinal viruses that can cause the disease, with the most common being Coxsackievirus A16 and Enterovirus 71. The main symptoms include recurrent fever, although some cases may not present with fever. There may also be symptoms such as drooling, and vesicles or papulovesicular rashes on the hands, feet, mouth, and buttocks. Additionally, some patients may exhibit lethargy, limb tremors, startle reactions, and vomiting. In severe cases, symptoms can include shortness of breath and coughing up pink frothy sputum, among others.