Hand, foot, and mouth disease is a rash illness characterized by scattered papules and vesicles on the hands, feet, mouth, and buttocks, caused by an enterovirus infection. It is a contagious disease caused by a viral infection, specifically by Coxsackievirus A16 and Enterovirus 71, which are part of the enterovirus group. Other Coxsackie enteroviruses can also cause hand, foot, and mouth disease. Common enterovirus infections can also lead to hand, foot, and mouth disease. This means that children who have had hand, foot, and mouth disease can potentially get it again, and this is important knowledge for everyone to understand.