Does ovarian cancer hyperthermic intraperitoneal chemotherapy work?

Written by Liu Liang
Oncology
Updated on November 05, 2024
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Patients with ovarian cancer are prone to peritoneal metastasis, so many patients develop ascites during the discovery of the disease or its progression. A large amount of ascites is a common concurrent symptom in patients with ovarian cancer. For patients with significant ascites like this, hyperthermic intraperitoneal chemotherapy (HIPEC) can be performed, which involves infusing chemotherapy drugs into the abdominal cavity and then combining it with thermotherapy. This treatment generally has a decent effect, especially in controlling the spread of cancer cells in the peritoneum and managing ascites.

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Written by Liu Liang
Oncology
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Does ovarian cancer cause abdominal pain every day?

Patients with ovarian cancer often experience abdominal pain as a common symptom. This is because ovarian cancer can widely implant itself within the pelvic and abdominal cavity, or directly invade the uterus, fallopian tubes, and other tissues and organs within the pelvis, resulting in symptoms of abdominal pain. However, not every patient with ovarian cancer will necessarily exhibit abdominal pain as a clinical symptom, nor is it the case that abdominal pain will occur every day. For instance, some patients with early-stage ovarian cancer may have more concealed clinical presentations and may not experience any specific discomfort. They might discover the disease through physical examinations, gynecological exams, or through ultrasound scans of the uterine adnexa conducted during physical check-ups.

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Oncology
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How is ovarian cancer diagnosed?

Ovarian cancer is discovered through transvaginal ultrasound of the adnexa uteri revealing ovarian tumors, or through imaging studies such as abdominal CT scans or MRIs showing ovarian tumors, combined with tumor markers, particularly the ovarian epithelial cancer tumor marker CA125, which will be significantly elevated. Generally, with these findings, ovarian cancer can typically be clinically diagnosed. Confirmation, however, requires pathological diagnosis, which involves obtaining a biopsy of the tumor. This can be done through a puncture biopsy or through pathological examination after surgical excision to confirm ovarian cancer. Additionally, some patients with ovarian cancer present with substantial ascites at the time of discovery. If cancer cells are found in the abdominal fluid, combined with a significant increase in CA125 and imaging studies showing ovarian tumors, ovarian cancer can also be diagnosed.

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Oncology
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ovarian cancer specific drug

Ovarian cancer does not have any specific cure-all treatment. Most ovarian cancers are epithelial ovarian cancers, and there is also ovarian cancer resulting from malignant germ cells, which is a rarer pathology type. For epithelial ovarian cancer, treatment methods include surgery, radiation therapy, chemotherapy, and some targeted therapies, mainly using Bevacizumab, which is a monoclonal antibody that inhibits angiogenesis, and is usually used in combination with chemotherapy drugs. For patients with advanced ovarian cancer, those who are resistant to chemotherapy, or those in poor general health unable to endure chemotherapy, palliative treatments like hormone treatment using progestogens are an option, along with immune therapy being available nowadays. Surgery is primarily for early-stage ovarian cancer patients, where curative surgical resection is possible, or for debulking surgery in patients with advanced ovarian cancer. Chemotherapy is frequently used as it is relatively effective for epithelial ovarian cancer, a type of cancer that is somewhat sensitive to such treatments. The drugs used mainly include taxane combined with platinum-based chemotherapy. For intravenous administration or intraperitoneal delivery—for the latter, mainly for ovarian cancers complicated by extensive ascites—, positioning an abdominal drainage tube and then infusing platinum-based chemotherapy drugs into the abdominal cavity are utilized.

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Oncology
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Will ovarian cancer recur after complete resection?

After complete removal of ovarian cancer, there is still a possibility of recurrence, especially in patients with high-risk factors. The recurrence rate can be quite high, for example, if there was rupture of the capsule, low differentiation of the pathology, presence of tumor tissue on the surface of the ovary, severe adhesion of the tumor to the surrounding areas, cancer cells found in the abdominal lavage fluid, or presence of vascular tumor thrombus and nerve invasion. Even after total removal, recurrence can still occur.

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How many years can one live with ovarian cancer?

The survival period of ovarian cancer patients is influenced by various factors including the specific stage of the cancer, whether there is residual tumor after surgery, the size of any residual tumor, the pathological type of the cancer, the presence of high-risk factors for recurrence such as vascular tumor thrombus, neural invasion, lymph node metastasis, etc., as well as the patient's age, overall condition, the presence of severe comorbidities, and the patient's response and sensitivity to treatments like radiotherapy and chemotherapy. Survival periods vary due to differences in stages and treatment sensitivities, meaning it cannot be generalized; there is significant individual variation in survival outcomes.