What is the fundamental difference between rickets and tetany?

Written by Yan Xin Liang
Pediatrics
Updated on June 09, 2025
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Rickets is a type of vitamin D deficiency disease, primarily caused by insufficient vitamin D in infants, children, or adolescents, leading to disorders in calcium and phosphorus metabolism. It is a chronic nutritional disease characterized by skeletal lesions, mainly manifesting as changes in the fastest growing parts of the skeleton, such as square skull, pigeon chest, funnel chest, bow legs, and knock knees, among other symptoms. On the other hand, tetany is primarily due to hypocalcemia and its manifestations differ; it does not exhibit the skeletal changes seen in rickets but primarily presents as spasms or cramps in the hands and feet. Thus, this constitutes their fundamental difference.

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Neonatology
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What department should I see for rickets?

Rickets is a nutritional disease caused by a deficiency of vitamin D, which leads to a disorder of calcium and phosphorus metabolism and consequently abnormal bone development. In the early and active stages of rickets, the main symptoms are low levels of vitamin D and disordered calcium and phosphorus metabolism. At this stage, bone development abnormalities may not be clearly noticeable, so it is recommended to consult an endocrinology department. During the residual stage, when skeletal deformities appear, rehabilitation treatment is necessary, and consultation with a pediatric rehabilitation department is advisable. Severe skeletal deformities may require surgical correction, necessitating consultation with an orthopedic department.

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Written by Yao Li Qin
Pediatrics
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The main manifestations of rickets in the early stage

Rickets generally refers to vitamin D deficiency rickets, mainly due to insufficient vitamin D in children, leading to calcium and phosphorus metabolism disorders. It is a chronic nutritional disease characterized by skeletal lesions. The main manifestations are changes in the fastest growing parts of the skeleton, which can also affect muscle development and changes in neural excitability. The initial symptoms of rickets are common in infants, especially those under three months old. The main symptom is increased neural excitability; the child is particularly prone to being agitated, irritable, crying, sweating, and shaking their head due to scalp stimulation, but these are not specific symptoms of rickets. Therefore, blood tests are still necessary in the early stages, showing decreased levels of 25-hydroxyvitamin D3, blood calcium, and blood phosphate, increased PTH, normal or slightly elevated alkaline phosphatase activity, and normal or slightly blurry calcification zones in skeletal X-rays. These are the early manifestations of rickets.

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How to diagnose rickets?

Rickets is caused by a deficiency of vitamin D, which leads to abnormal calcium and phosphorus metabolism, and thus abnormal bone development. Generally, rickets requires biochemical blood tests and vitamin D level assessments, followed by skeletal X-ray examinations. However, some cases of rickets are caused by other special reasons, such as abnormalities in liver and kidney functions, and there may also be congenital genetic diseases. Therefore, rickets also requires further related examinations, such as liver function tests, kidney function tests, and parathyroid hormone tests, and even some genetic level examinations might be conducted.

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Can rickets be treated by injection?

Rickets is primarily caused by a deficiency of vitamin D, leading to a disturbance in calcium and phosphorus metabolism in the body, which results in abnormal bone development. It is a systemic nutritional and chronic disease. The main treatment is to supplement a sufficient dosage of vitamin D, generally administered orally. The choice of vitamin D formulation, dosage, duration of treatment, whether it is administered once or multiple times, and whether supplementation is oral or intramuscular, should be determined based on the specific situation of the child. Relevant tests are generally required, and the doctor will develop a treatment plan based on the child's condition. The route of administration should also be decided based on the condition of the disease.

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Clinical manifestations of rickets

Rickets, also known as vitamin D deficiency rickets, occurs because children do not supplement vitamin D in a timely manner after birth, leading to a deficiency of vitamin D in the body and resulting in a nutritional metabolic disease primarily involving skeletal changes. In the early stages, children mainly show symptoms related to mental and emotional state, such as irritability, crying, excessive sweating, shaking their heads back and forth, and rubbing their heads. Subsequently, symptoms like bald patches on the back of the head and softening of the skull bones may appear. As children grow, they may develop conditions such as a square-shaped skull, beaded ribs, pigeon chest, funnel chest, and bracelet-like deformities around the wrists and ankles. In severe cases, children may later develop X-shaped legs and O-shaped legs. If rickets is suspected, it is crucial to promptly conduct a blood test to measure the vitamin D level. If the level is below normal, it is essential to actively treat the diagnosed rickets.