Which is more serious, pulmonary nodules or thyroid nodules?

Written by Yuan Qing
Pulmonology
Updated on March 24, 2025
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It is impossible to compare the severity between thyroid nodules and lung nodules.

Firstly, thyroid nodules and lung nodules occur in different organs. Lung nodules are mostly caused by inhalation of dust, pollutants, or smoke.

Thyroid nodules, on the other hand, often result from genetic factors, or issues with the patient’s own constitution leading to the formation of these nodules. Most lung nodules can be classified as benign or malignant through diagnostic tests, whereas it is often difficult to assess the nature of thyroid nodules with standard tests. Additional auxiliary examinations, such as PET-CT or SPECT, and biopsy pathology are needed to determine the nature of thyroid nodules.

Therefore, the approaches to observing and handling these two types of nodules are entirely different, and they cannot be compared.

Other Voices

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Written by Li Jin Quan
General Surgery
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How to Treat Calcification of Thyroid Nodules

In the treatment of thyroid nodule calcification, we generally decide based on the size of the calcification. Usually, larger calcifications have a lower malignancy rate. Such calcifications can continue to be observed. Depending on specific circumstances, a fine needle aspiration cytology test may be chosen. Depending on the results of the pathological examination after the aspiration, we decide the next treatment approach, whether to continue observation or proceed with surgery. The second type involves smaller calcifications, which relatively have a higher malignancy rate. Our preferred treatment is surgery. During the surgery, based on the medical examination results, if the nodule is malignant, we need to further devise other treatment plans, including expanded surgery, radiotherapy, etc.

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Written by Li Jin Quan
General Surgery
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How to deal with calcification of thyroid nodules?

Thyroid nodules calcification can be divided into coarse calcification and microcalcification. Coarse calcification is generally benign, and benign conditions do not require special treatment. When a large nodule causes compression symptoms and affects our appearance, surgical removal can be considered. Microcalcification is mostly likely to become malignant, therefore, cytological biopsy of the thyroid should be performed. If it is benign, we can continue to observe it. If it is malignant, we can treat it with surgery, comprehensive therapy, or radiotherapy.

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Written by Hu Jian Zhuo
Nephrology and Endocrinology
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Does thyroid nodule puncture hurt?

Fine needle aspiration is an invasive examination, but it is currently an important and most efficient method for assessing benign and malignant conditions, generally conducted under ultrasound guidance. Thyroid nodule aspiration does not cause much pain, similar to that of an injection. Anesthetics are used during the procedure, so the pain is not very noticeable. However, as the effect of the anesthetic wears off, there may still be some pain at the puncture site, but the patients do not need to carry a heavy psychological burden.

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Written by Luo Han Ying
Endocrinology
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Post-thyroidectomy complications

In clinical practice, for large thyroid nodules that cause compressive symptoms, such as difficulty swallowing, breathlessness, and hoarseness, thyroid nodule excision surgery can be performed. However, this surgery can have sequelae. First, if the excised thyroid tissue is too large, it can easily lead to reduced thyroid function, requiring lifelong supplementation with thyroid hormones for treatment. Secondly, due to the sensitive location of the thyroid gland, which is surrounded by various glands and nerves, injury during surgery can lead to complications such as seizures and hoarseness, which are considered post-surgical sequelae.

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Written by Chen Xie
Endocrinology
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The difference between thyroid enlargement and thyroid nodules

Thyroid enlargement generally refers to simple thyroid enlargement, which is typically diffuse thyroid enlargement, mainly caused by iodine deficiency, commonly seen in endemic goiter and physiological thyroid enlargement. Thyroid nodules, on the other hand, are nodular hyperplasia of the thyroid caused by certain physical and chemical factors. Thyroid nodules can manifest as benign hyperplasia or malignant hyperplasia. Therefore, the risks associated with thyroid nodules are relatively greater than those of thyroid enlargement. However, some patients with thyroid enlargement, as the disease progresses, can develop nodular hyperplasia of the thyroid. These are the differences between the two.