Can people with ankylosing spondylitis have children?

Written by Li Jing
Rheumatology
Updated on November 13, 2024
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Firstly, ankylosing spondylitis is an autoimmune disease and is chronic. This disease cannot be cured; rather, it is managed long-term through medications to alleviate symptoms, control the progression of the condition, and delay the onset of joint deformities, which is the main purpose of treatment. This disease is not hereditary, but there is a clear phenomenon of familial aggregation. For instance, if one or both parents have it, the incidence in their children is over 50%. Patients with ankylosing spondylitis can have children, but there is a very high probability that their children will also suffer from the disease. Additionally, it is advised not to conceive while on medication during the treatment period; one must stop taking the medication for more than three months before considering pregnancy.

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Written by Yang Ya Meng
Rheumatology
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What is the ESR level in ankylosing spondylitis?

Patients with ankylosing spondylitis, if not well controlled, can exhibit elevated erythrocyte sedimentation rates (ESR). An ESR higher than 20 mm per hour indicates elevation, suggesting poor disease control. At such times, it is necessary to utilize non-steroidal anti-inflammatory drugs (NSAIDs) such as sustained-release diclofenac sodium tablets. Additionally, medications that control the condition should also be used, like sulfasalazine tablets and thalidomide, among others. While biological agents, commonly tumor necrosis factor (TNF) antagonists, offer the best treatment effectiveness, they are also the most expensive. (The use of medications should be conducted under the guidance of a physician.)

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Written by Yang Ya Meng
Rheumatology
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What tests are done for ankylosing spondylitis?

The main laboratory indicators for ankylosing spondylitis include the following: Testing for the B27 gene, formally known as HLA-B27 gene, which is hereditary and commonly found in male patients. Second, to determine if ankylosing spondylitis is in an active phase, inflammatory markers such as erythrocyte sedimentation rate and C-reactive protein can be checked. Moreover, the diagnosis of ankylosing spondylitis must involve the sacroiliac joints being affected. Therefore, a CT scan and MRI of the sacroiliac joints can be conducted to determine if there are issues with the sacroiliac joints. If the patient shows symptoms of inflammatory lower back pain, has affected sacroiliac joints, tests positive for the B27 gene, and shows elevated inflammatory markers, then a diagnosis of ankylosing spondylitis can generally be confirmed.

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Written by Yang Ya Meng
Rheumatology
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How to relieve ankylosing spondylitis

Methods to alleviate ankylosing spondylitis are as follows: First, in terms of lifestyle: during the remission phase of ankylosing spondylitis, it is necessary to persist in long-term functional exercises to keep the spine from adhering and becoming rigid. The second and most important aspect is the long-term use of medication. The medications used to treat ankylosing spondylitis mainly include the following categories: The first category is non-steroidal anti-inflammatory drugs, commonly used ones include diclofenac sodium sustained-release tablets, celecoxib capsules, etc.; the second category includes disease-controlling medications such as sulfasalazine, thalidomide, methotrexate, and even leflunomide. Currently, the most effective medications for treating ankylosing spondylitis are biologics. However, before using biologics, it is essential to strictly rule out diseases such as hepatitis, tuberculosis, and tumors. (Medications should be used under the guidance of a doctor based on specific conditions.)

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Written by Sun Shu Jian
Orthopedics
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Early symptoms of ankylosing spondylitis

The early symptoms of ankylosing spondylitis mainly include insidious onset of pain and discomfort in the back and hip joints. The pain is often intermittent and worse at night. Patients frequently wake up at night due to back pain, which can be alleviated by slight movement. Therefore, when patients experience unexplained back and hip joint pain, it is necessary to determine whether ankylosing spondylitis could be a possibility. In the early stages, a sacroiliac joint CT scan and hematological examination can be performed to confirm the diagnosis. Once diagnosed, prompt standardized treatment is necessary. Generally, this can control synovial inflammation and pain, prevent deformities of the spine and joints, and help patients return to normal life and work.

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Written by Li Jing
Rheumatology
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Does ankylosing spondylitis have a genetic component?

Firstly, ankylosing spondylitis is a chronic disease that primarily affects the axial joints, and this disease is incurable. It can only be managed with medications to control the progression of the disease, delay the appearance of joint deformities, and reduce disability. This is the main purpose of its treatment. The cause of the disease is also unclear, and it is somewhat related to genetics. If parents have it, the incidence in their children is significantly increased, and there is a phenomenon of familial aggregation. It cannot be considered a hereditary disease, but there is indeed a phenomenon of familial aggregation. Moreover, the incidence of the disease in children is much higher than in families without a history of the disease.