Ankylosing spondylitis is an autoimmune disease and a chronic condition. It primarily involves damage to the axial joints. Additionally, extrajoint manifestations can occur, such as iritis, keratitis, and corneal perforation. Currently, there is no effective cure for ankylosing spondylitis, meaning it cannot be completely cured. The treatment focuses on long-term medication management to control symptoms, delay complications, improve quality of life, and reduce disability rates. This is the main goal of treatment. Without proper treatment, deformities in the joints and spinal ankylosis can develop within a relatively short period, about seven to eight years, leading to a hunched back and significant restriction in joint mobility. Proper treatment can significantly delay joint damage. Regarding whether ankylosing spondylitis can lead to paralysis, it does not cause paralysis but does result in decreased energy and ability for activities such as turning, twisting the head, or bending, which are significantly restricted.