Complications of ankylosing spondylitis

Written by Li Jing
Rheumatology
Updated on June 06, 2025
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Firstly, ankylosing spondylitis is a chronic autoimmune disease that primarily damages the axial joints, and currently, there is no specific cure for it. This means that the disease cannot be completely cured but can only be managed with medications to alleviate symptoms, delay complications, improve quality of life, and reduce disability rates. If this disease is not treated properly, it can lead to joint deformities, muscle rigidity, and spinal stiffness. Once the spine becomes stiff, functional impairments occur, at which point the quality of life decreases, and surgery may need to be considered. If there is a subluxation of the joint, joint fusion surgery must be considered. Changes can also occur in the peripheral joints, in which case joint replacement might be considered.

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Written by Li Jing
Rheumatology
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Ankylosing Spondylitis Test Items

Ankylosing spondylitis is a systemic disease of unknown cause, primarily characterized by chronic inflammation of the axial joints. It mainly affects the sacroiliac joints and leads to bony ankylosis, predominantly occurring in males, especially young males. The disease has a significant familial genetic tendency. The main symptoms are pain or discomfort in the lower back and back, typically occurring at night, accompanied by difficulty turning over. Stiffness is evident in the morning or after sitting for a long time, but symptoms may alleviate after physical activity. In young and middle-aged males showing these symptoms, ankylosing spondylitis should be suspected first. The main diagnostic methods include blood tests for HLA-B27, and imaging such as CT or MRI of the sacroiliac joints to detect any sacroiliitis. Diagnosis primarily relies on the combination of symptoms, HLA-B27 results, and sacroiliac joint CT findings.

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Written by Li Jing
Rheumatology
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Is ankylosing spondylitis hereditary?

Ankylosing spondylitis is a systemic autoimmune disease of unclear etiology characterized by chronic inflammation primarily affecting the axial joints, mainly involving the sacroiliac joint. The cause is unclear, and research by experts has shown that the disease tends to run in families, indicating familial clustering. It is not classified as a genetic disease, but there is both familial clustering and a genetic predisposition, meaning that if parents have the disease, their children are much more likely to develop it compared to others. Therefore, if symptoms such as lower back pain or neck stiffness occur, it is advisable to undergo thorough examinations and seek early diagnosis and treatment to delay joint deformity and control the progression of the disease.

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Written by Na Hong Wei
Orthopedics
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What is Ankylosing Spondylitis?

Ankylosing Spondylitis (AS), where "A" stands for fusion and "S" for spine, refers to the condition where the bones and joints of the spine are fused together. Ankylosing Spondylitis is defined as a chronic inflammatory disease primarily affecting the axial skeleton and major limb joints. It is characterized by fibrosis and ossification of the intervertebral discs’ annulus fibrosus and nearby connective tissues, as well as ankylosis (stiffening) of the joints. It presents as a sterile inflammation occurring in the spine. However, it is not solely limited to the spine as it also involves the axial bones and major limb joints. The pathological hallmark of the disease includes inflammation mainly at the sacroiliac joints and points of attachment to the spine, leading to joint stiffness and calcification of the spinal ligaments and joints. The disease progression begins at the sacroiliac joint, spreading upwards through the entirety of the spine, and eventually stops at the cervical vertebrae. Symptoms start with pain in the early stages, followed by restricted mobility in the intermediate phase, and ultimately leading to deformities of the abdomen and back, culminating in severe hunchback. The exact cause of Ankylosing Spondylitis remains unclear, with various theories proposed but none universally accepted. Additionally, it is categorized under rheumatologic and immunologic disorders.

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Written by Yang Ya Meng
Rheumatology
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Is moxibustion useful for ankylosing spondylitis?

Patients with ankylosing spondylitis are not recommended to receive moxibustion treatment because it can easily cause skin burns and local soft tissue infections. Moreover, moxibustion does not address the root cause of ankylosing spondylitis. It is recommended to continue with regular oral medication treatments. The medications used to treat ankylosing spondylitis mainly include non-steroidal anti-inflammatory drugs (NSAIDs), such as sustained-release diclofenac sodium. Commonly used medications to control the condition include sulfasalazine and thalidomide. Currently, the most effective treatment for ankylosing spondylitis involves biologic agents, commonly tumor necrosis factor (TNF) inhibitors. (Please use medications under the guidance of a doctor.)

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Written by Yang Ya Meng
Rheumatology
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Is ankylosing spondylitis serious?

Patients with ankylosing spondylitis, if treated actively in the early stages, the condition is not severe. However, if the patient continues to seek irregular and improper medical care, it is possible to develop severe complications such as kyphosis and spinal ankylosis. In severe cases, patients may even self-harm. Therefore, it is advised that patients with ankylosing spondylitis seek treatment early, before the onset of spinal ankylosis. The treatment plan mainly includes non-steroidal analgesics, such as diclofenac sodium sustained-release tablets, medications to control the condition, such as sulfasalazine tablets, and biologic treatments. With the above treatments, the condition of ankylosing spondylitis can be controlled. (Medication use should be under the guidance of a doctor.)