What causes obesity?

Written by Tang Zhuo
Endocrinology
Updated on March 15, 2025
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Obesity, also known as adiposis, is a chronic metabolic disease caused by excessive accumulation of fat in the body or abnormal distribution of fat. The causes of obesity are numerous and complex. The exact cause is not clear, but it is believed to include a variety of factors such as genetics and environment, which interact with each other. From the perspective of genetic factors, the probability of developing obesity significantly increases. The second factor, the environment, mainly includes diet and physical activity. Long periods of sitting or lack of sports, and insufficient physical activity can lead to reduced energy expenditure. Poor dietary habits, such as overeating, a preference for sweets or greasy foods, can easily lead to obesity. Thirdly, it can be due to some genetic abnormalities. Fourth, obesity in childhood is also more likely to progress to adult obesity, with more than 50% of individuals who are obese after the age of six developing obesity in adulthood.

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Written by Chen Li Ping
Endocrinology
1min 18sec home-news-image

Will obesity be inherited?

The primary cause of simple obesity, where the reason for being overweight is unclear, is an energy intake that exceeds energy expenditure. There are also certain genetic factors involved. Generally, it is believed that susceptibility to obesity varies among human races, along with the presence of obesity genes and variations in genes related to obesity. Additionally, an individual’s metabolic type, appetite, digestive absorption functions, sleep quality, and metabolic efficiency form the basis for the development of simple obesity. Poor lifestyle habits, such as insufficient physical activity and excessive energy intake, are necessary conditions for its occurrence. Epidemiological surveys have shown that most people with simple obesity have a familial tendency towards the condition. Children born to obese parents are 5-8 times more likely to develop simple obesity than those born to parents who both have a normal weight. However, the majority of cases of simple obesity are not caused by obesity genes or mutations in genes related to obesity.

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Written by Luo Juan
Endocrinology
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The causes of obesity

Obesity can be classified into primary and secondary obesity according to its causes. Primary obesity, also known as simple obesity, is the most common type among various forms of obesity. It is mainly caused by poor dietary habits such as overeating, especially excessive intake of fatty foods, and a sedentary lifestyle, rather than being secondary to other diseases. Secondary obesity, on the other hand, is often due to diseases of the hypothalamic-pituitary axis, hypercortisolism, hypofunction of the thyroid or gonads, insulinomas, and other diseases. Secondary obesity is mainly due to diseases, and it can show some symptoms of the underlying disease.

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Written by Zhao Xin Lan
Endocrinology
57sec home-news-image

What department should I go to for obesity?

Obesity is a chronic metabolic disease that belongs to the field of endocrinology, so the first choice for early-stage obesity is to see an endocrinologist. Some hospitals also have specialized weight management departments, which are also an option for consultation. When obesity is accompanied by other serious comorbid conditions, such as coronary heart disease or heart failure, in addition to seeing an endocrinologist, it is also necessary to visit the cardiology department. If there is concomitant osteoarthritis, a visit to the orthopedics department is needed. Women suffering from menstrual irregularities or infertility should consult with a gynecologist. In summary, obesity is a disease that can cause multiple metabolic abnormalities and damage multiple systems, requiring early prevention and treatment.

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Written by Li Lang Bo
Endocrinology
1min 28sec home-news-image

What medicine is taken for obesity?

Regarding obesity, first and foremost, one should not eat arbitrarily, meaning one should not randomly choose the so-called weight loss drugs available on the market. For obesity, we identify two types: primary obesity and secondary obesity. Primary obesity occurs without any specific reason, merely due to an irregular lifestyle, unhealthy diet, lack of exercise, etc., leading to weight gain. Secondary obesity has identifiable medical causes; for example, weight gain caused by taking large amounts of exogenous hormones; or hypothyroidism leading to myxedema, which causes weight gain; or issues with the pituitary or adrenal glands leading to excessive secretion of cortisol in the blood, causing a redistribution of fat that results in Cushing's syndrome, among others. For these types of secondary obesity, it is important to identify the underlying causes and treat them accordingly. For primary obesity, it is not advisable to recommend weight loss drugs commonly found on the market. The first recommendation is to control the diet scientifically, combined with a certain intensity of aerobic exercise to reduce weight. Caution is advised with those weight loss drugs sold by online marketers; one should not consume them carelessly.

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Written by Luo Juan
Endocrinology
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Obesity.

Obesity is a metabolic disease that occurs when the caloric intake of the human body exceeds the calories burned. The surplus calories are stored in the body as fat. When the amount of accumulated fat exceeds the normal physiological needs and reaches a certain level, it develops into obesity. Therefore, obesity is the manifestation of excess calories stored as fat in the body. There are many methods to assess obesity, with the Body Mass Index (BMI) being one of the most common. The formula for calculating BMI is weight divided by height squared. In China, a BMI of 28 or greater is generally considered obese.