Late-stage symptoms of gastric cancer

Written by Liu Liang
Oncology
Updated on September 05, 2024
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The common late-stage symptoms of gastric cancer patients include nausea, vomiting, and even a complete inability to eat. There are also symptoms related to the digestive tract such as pain in the upper abdomen and acid reflux, as well as upper gastrointestinal bleeding, such as vomiting blood and melena which are signs of lower gastrointestinal bleeding. Late-stage gastric cancer patients may also experience organ metastasis, leading to corresponding symptoms. For example, metastasis of gastric cancer to the liver can cause abdominal pain and ascites due to hepatic metastatic tumors. Clinical manifestations caused by such metastatic tumors also include metastasis to retroperitoneal lymph nodes in the abdominal cavity, a common site of spread for gastric cancer. Patients may even show symptoms of intestinal obstruction, such as abdominal pain, bloating, nausea, vomiting, inability to pass stool, or even absence of flatus, which are indicators of intestinal obstruction. Consequently, patients might experience weight loss and deteriorate into a cachectic state, marked by poor nutrition and significant weight loss, which are characteristic symptoms of late-stage patients.

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Oncology
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How is gastric cancer caused?

The causes of gastric cancer are not yet clearly understood. However, its occurrence is associated with poor dietary habits, such as irregular eating—sometimes skipping a meal, sometimes overeating, not having meals on time—and consuming pickled food, barbecued junk food, and other unhealthy dietary practices. Additionally, smoking, alcohol consumption, infection with Helicobacter pylori, chronic gastric diseases such as atrophic gastritis, and genetic factors are all somewhat related to the development of this condition.

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Oncology
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How to treat advanced gastric cancer?

The treatment for advanced gastric cancer is primarily chemotherapy, especially for patients with peritoneal or retroperitoneal lymph node metastasis, or distant organ metastasis such as to the liver or lungs. The treatment primarily involves chemotherapy, specifically choosing either multi-drug intravenous combination chemotherapy or oral monotherapy, such as oral chemotherapy with tegafur capsules, or broad-spectrum targeted therapies like apatinib that inhibit angiogenesis. The choice of treatment depends on a comprehensive consideration of the patient's overall condition. If the patient's general condition is particularly poor and the chemotherapy risk is assessed to be high, then the approach for such advanced-stage patients is primarily the best symptomatic supportive treatment to alleviate suffering as much as possible. Therefore, the treatment plan must be determined based on a comprehensive consideration of the specific situation.

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Can stomach cancer be cured?

Whether gastric cancer can be cured depends greatly on the stage at which it is discovered. Clinically, if there is no recurrence or metastasis within five years, it is considered cured. The treatment of gastric cancer is primarily surgical. Therefore, for early-stage gastric cancer patients, if a surgeon assesses that curative surgery is feasible, it is recommended to perform a radical surgical resection. For stage I gastric cancer patients, the five-year survival rate after surgical treatment can generally reach over 90%, which is quite effective. However, for those with advanced gastric cancer, it is generally incurable. Treatments, including chemotherapy, targeted therapy, or optimal symptomatic supportive care, aim to alleviate the patient's suffering and extend their life, but generally cannot cure advanced gastric cancer.

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Can stomach cancer be cured?

Whether gastric cancer can be cured depends on the stage of the cancer, as well as the patient's own physical condition. For example, early-stage gastric cancer patients, who are diagnosed as early-stage through examinations such as endoscopic ultrasonography and enhanced CT of the chest and abdomen, and assessed by surgeons as suitable for curative surgery, are primarily treated with curative surgery. The prognosis for these early-stage gastric cancer patients is generally good, with a relatively high five-year survival rate. Post-operation, based on the pathological findings, it is decided whether postoperative adjuvant radiotherapy and chemotherapy are necessary. There is hope for curing patients in these early stages through these treatment methods. However, if a patient is found to have advanced-stage gastric cancer, for example with metastases to distant organs like the liver and lungs, the cancer is not completely curable. The purpose of treatment in such cases is to alleviate the patient's pain and extend their survival, but it can’t achieve a curative effect.

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How to check for gastric cancer?

When clinical symptoms such as nausea, vomiting, gastric distension or upper abdominal pain, acid reflux, or hematemesis, as well as melena occur, it is necessary to consider the possibility of gastric cancer and seek timely medical attention. Completing a gastroscopy and obtaining a biopsy under gastroscopy are essential. If cancer cells are found, this is the most important diagnostic method for confirming gastric cancer. After the diagnosis of gastric cancer, further examinations like endoscopic ultrasound and CT scans of the chest and abdomen are required to assess the approximate stage of the patient and to decide the subsequent treatment plan.