The main causes of headaches in lupus are as follows: First, lupus cerebritis. Headache is a common symptom of lupus cerebritis, with other frequent occurrences including epileptic seizures. Second, it is associated with infectious diseases, such as catching a cold. Headache is one of the most common clinical symptoms of a cold. Third, it involves mental abnormalities. Patients may experience headaches and other discomforts related to mental abnormalities. Fourth, it is associated with cerebrovascular diseases, such as encephalitis and meningitis. Fifth, it involves cardiovascular diseases, such as hypertension. Severe hypertension can manifest symptoms such as headaches and dizziness. If a patient with lupus experiences headaches, it is important to first seek a definitive diagnosis at a hospital, followed by determining a detailed treatment plan.