Lupus is what disease?

Written by Zhang Lin
Rheumatology and Immunology Nephrology
Updated on September 12, 2024
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Lupus erythematosus, also known as systemic lupus erythematosus, is a chronic autoimmune disease involving multiple systems and organs. Patients' serum contains various autoantibodies, with the main pathological changes being inflammatory reactions and vascular abnormalities. Most patients exhibit butterfly-shaped erythema on the bridge of the nose and cheeks, which is the most characteristic manifestation of lupus erythematosus. The clinical presentations of systemic lupus erythematosus are diverse, generally characterized by the "four multiples": involvement of multiple systems, multiple organs, multiple autoantibodies, and a higher prevalence among women of childbearing age. Without proper and effective treatment, the mortality rate is high, with the main causes of death being infections, renal failure, and damage to the central nervous system.

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Written by Li Jing
Rheumatology
55sec home-news-image

What causes lupus erythematosus?

Firstly, systemic lupus erythematosus is a chronic, multi-systemic, systemic autoimmune disease that commonly occurs in women of childbearing age, more frequently seen in females, with a significantly higher incidence rate in females than in males. The cause is currently unclear, only indicating that experts believe it is related to environmental pollution, viral infections, hormone levels, genetics, etc., but there is no definitive evidence proving which factors it is related to, only stating that there are studies linking it to these factors. Its clinical manifestations also vary, with most cases having a gradual onset, characterized by recurrent erythema, even pustules, Raynaud's phenomenon, etc. A minority of patients may have a sudden onset, primarily presenting with major hematologic damage.

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Written by Zhang Lin
Rheumatology and Immunology Nephrology
1min 2sec home-news-image

Can lupus be inherited?

Lupus erythematosus is not a genetic disease, but it is a disease with a genetic predisposition. This means that genetic diseases refer to monogenic diseases, including albinism, color blindness, etc., which are determined by a pair of alleles. However, lupus erythematosus is a disease with a genetic predisposition, determined by multiple genes. Although lupus erythematosus is not a genetic disease, if your parents have lupus erythematosus, the chance of the next generation developing lupus erythematosus is about 1% to 16%. This relationship is especially significant between mothers and daughters, and among sisters. Genetic factors account for approximately 20% of the importance in the development of lupus erythematosus. Only the combination of genetic factors and environmental factors together can lead to the occurrence of lupus erythematosus.

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Written by Zhang Lin
Rheumatology and Immunology Nephrology
56sec home-news-image

Lupus is what disease?

Lupus erythematosus, also known as systemic lupus erythematosus, is a chronic autoimmune disease involving multiple systems and organs. Patients' serum contains various autoantibodies, with the main pathological changes being inflammatory reactions and vascular abnormalities. Most patients exhibit butterfly-shaped erythema on the bridge of the nose and cheeks, which is the most characteristic manifestation of lupus erythematosus. The clinical presentations of systemic lupus erythematosus are diverse, generally characterized by the "four multiples": involvement of multiple systems, multiple organs, multiple autoantibodies, and a higher prevalence among women of childbearing age. Without proper and effective treatment, the mortality rate is high, with the main causes of death being infections, renal failure, and damage to the central nervous system.

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Written by Liu Li Ning
Rheumatology
1min home-news-image

What is lupus and is it serious?

Lupus erythematosus is an autoimmune disease, which can be very severe in some cases and mild in others. For example, cutaneous lupus erythematosus generally does not involve major organs and usually presents with mild symptoms, primarily affecting the skin and mucous membranes. However, systemic lupus erythematosus can affect significant organs like the kidneys and heart in many patients, often leading to severe medical conditions. Especially, patients with rapidly progressive glomerulonephritis and those with coronary atherosclerotic heart disease tend to have a higher mortality rate. If systemic lupus erythematosus is diagnosed, it is crucial to receive standardized treatment early. Typically, treatment involves long-term maintenance with corticosteroids and immunosuppressants to control the progression of the disease and reduce the likelihood of mortality.

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Written by Liu Li Ning
Rheumatology
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What happens if someone with lupus occasionally drinks alcohol?

Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect multiple systems and organs throughout the body and is more commonly seen in women, particularly during their childbearing years. Clinically, it is mainly characterized by fever, rash, joint pain, oral ulcers, and hair loss. In terms of diet, it is recommended to eat light and avoid spicy and irritating foods. It is crucial to strictly abstain from smoking and drinking, avoid excessive fatigue, and direct sun exposure. Importantly, patients should strictly follow medical advice regarding medication and have regular check-ups.