Is lupus contagious?

Written by Zhang Lin
Rheumatology and Immunology Nephrology
Updated on September 03, 2024
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Lupus erythematosus is not contagious. The occurrence of lupus erythematosus is related to genetic factors, the levels of sex hormones in the body, and certain environmental factors that the body is exposed to. It is the combined effect of these factors that lowers the body's immune tolerance, causing disorder in immune function, and thus leading to this autoimmune disease. Therefore, unlike diseases caused by various pathogens, it cannot be transmitted from person to person. When normal individuals come into contact with patients, there is no need to fear contagion or to isolate the patients. During the remission and stable phases of the disease, lupus patients can engage in regular work, study, and participate in social activities just like healthy individuals.

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Written by Zhang Lin
Rheumatology and Immunology Nephrology
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How is lupus treated?

The treatment of lupus erythematosus mainly involves the following aspects: Firstly, mild patients can be treated with antimalarial drugs, such as chloroquine or hydroxychloroquine, thalidomide, and low-dose corticosteroids; moderate active patients can receive individualized treatment with corticosteroids, and immunosuppressants may be used when necessary; for severe patients, corticosteroids are the preferred treatment, combined with immunosuppressants such as cyclophosphamide. Secondly, for lupus crisis patients, treatment can involve immunoglobulin, high-dose corticosteroid pulse therapy. Thirdly, biologics, such as anti-CD20 monoclonal antibodies, plasmapheresis, and autologous stem cell transplantation, are also used clinically. Medication for treating lupus erythematosus should be used under the guidance of a doctor, and self-medication should be avoided to prevent serious consequences.

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Written by Liu Li Ning
Rheumatology
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What does the early rash of lupus look like?

The early characteristic rash of lupus erythematosus is typically a butterfly-shaped rash on the face. Other common presentations include palm and periungual erythema, discoid rash, nodular erythema, and livedo reticularis. If the rash is not notably itchy, it generally indicates lupus erythematosus. If there is significant itching, it may suggest the possibility of an allergic factor active in the disease. After immunosuppression, itchy rashes should be monitored for possible fungal infections. The specific pathogenesis of systemic lupus erythematosus is still unclear. If a patient exhibits the typical butterfly-shaped rash on the face, systemic lupus erythematosus should be highly suspected. Testing for antinuclear antibodies, and specifically for anti-Sm and double-stranded DNA antibodies, which represent a variety of autoantibodies, can diagnose systemic lupus erythematosus.

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Written by Zhang Lin
Rheumatology and Immunology Nephrology
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What should I do if lupus causes hair loss?

What should be done when a lupus patient experiences hair loss? Patients with lupus should keep their hair clean in daily life, not use too much shampoo when washing their hair, avoid dyeing or perming their hair, and reduce the damage to hair from chemical products. This prevents rashes or worsening rashes caused by allergies to hair dyes and damage to hair quality from perming. If hair loss occurs due to the effect of medications, patients can choose to wear a wig during treatment. After chemotherapy ends, new hair will grow, so patients need not worry excessively. Maintaining a pleasant mood is also quite important for recovery from the disease. The basic pathological change in lupus patients is vasculitis. When the small blood vessels in the skin become inflamed, the nutrient supply to the hair follicles is disrupted, which can easily lead to hair loss and affect hair growth. Generally, hair can regrow after the disease is controlled. If hair loss occurs again, it could be a symptom of a disease relapse.

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Written by Zhang Lin
Rheumatology and Immunology Nephrology
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Can lupus patients get pregnant?

Patients with lupus can conceive normally, but it is not recommended to become pregnant. This is because patients with lupus who become pregnant are prone to miscarriage, preterm birth, stillbirth, and poor fetal development in the uterus, especially in patients who are positive for antiphospholipid antibodies. Pregnancy can also aggravate the disease or cause a relapse in lupus patients, and even if the disease is stable, there are cases where the condition worsens during pregnancy or after childbirth. Therefore, it is not recommended for patients with active systemic lupus erythematosus to become pregnant. If the condition has been stable for more than a year after treatment and the patient has been off medication for at least 6 months, then pregnancy can be considered. However, it is important to note that dexamethasone, immunosuppressants, and Tripterygium wilfordii tablets have side effects on the fetus and should be avoided.

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Written by Zhang Lin
Rheumatology and Immunology Nephrology
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Can lupus be inherited?

Lupus erythematosus is not a genetic disease, but it is a disease with a genetic predisposition. This means that genetic diseases refer to monogenic diseases, including albinism, color blindness, etc., which are determined by a pair of alleles. However, lupus erythematosus is a disease with a genetic predisposition, determined by multiple genes. Although lupus erythematosus is not a genetic disease, if your parents have lupus erythematosus, the chance of the next generation developing lupus erythematosus is about 1% to 16%. This relationship is especially significant between mothers and daughters, and among sisters. Genetic factors account for approximately 20% of the importance in the development of lupus erythematosus. Only the combination of genetic factors and environmental factors together can lead to the occurrence of lupus erythematosus.