Will the rash of lupus fade away?

Written by Zhang Lin
Rheumatology and Immunology Nephrology
Updated on September 08, 2024
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Patients with lupus often experience recurrent, stubborn skin lesions on their hands or face, and some may even develop ulceration, atrophy, or scarring on top of the existing erythema. Most lupus patients exhibit erythema, centered around the bridge of the nose and appearing on the cheeks. The lesions are disc-like on both sides with generally clear boundaries, either flat or slightly raised, and are categorized as exudative inflammation. Depending on the severity of the inflammation, the erythema can range from light red, bright red to purple-red. In severe cases, localized edema resembling erysipelas may occur, and scaling and hyperpigmentation may appear as the inflammation subsides. Facial rashes generally resolve, and most rashes do not leave marks after resolution. If hyperpigmentation remains after the erythema has resolved, it suggests a good prognosis. However, erythema in other areas, such as acral erythema and reticular cyanosis, may last for varying durations depending on the patient's individual condition.

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Written by Li Jing
Rheumatology
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What causes lupus erythematosus?

Firstly, systemic lupus erythematosus is a chronic, multi-systemic, systemic autoimmune disease that commonly occurs in women of childbearing age, more frequently seen in females, with a significantly higher incidence rate in females than in males. The cause is currently unclear, only indicating that experts believe it is related to environmental pollution, viral infections, hormone levels, genetics, etc., but there is no definitive evidence proving which factors it is related to, only stating that there are studies linking it to these factors. Its clinical manifestations also vary, with most cases having a gradual onset, characterized by recurrent erythema, even pustules, Raynaud's phenomenon, etc. A minority of patients may have a sudden onset, primarily presenting with major hematologic damage.

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Written by Zhang Lin
Rheumatology and Immunology Nephrology
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Can people with lupus eat beef?

For patients with lupus, we recommend eating less beef. This is because our dietary guidelines for lupus patients are: high protein, low fat, low salt, low sugar, and foods rich in various vitamins and calcium. Since beef is a high-phenylamine protein food, it is advised to consume less of it. Patients can eat some fish, lean meat, chicken, and duck, depending on their financial situation, to supplement the protein lost in the kidneys but should not eat too much to avoid indigestion. The diet for lupus patients should be light, and when cooking, food should not be too oily or too spicy.

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Written by Zhang Lin
Rheumatology and Immunology Nephrology
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What are the symptoms of the early stage of lupus erythematosus?

The main symptom in the early stage of lupus is the appearance of a butterfly-shaped rash on the face, with most patients initially exhibiting these rashes, some of which are not butterfly-shaped. The rash can also appear on fingers, palms, and around the nails. Additionally, over 80% of patients experience unexplained fevers, which are irregular and can sometimes reach up to 40 degrees Celsius. Some patients also experience joint pain in the early stages of the disease, mainly starting with pain in larger joints such as the elbows, knees, and ankles. If joint pain is accompanied by fever, rash, and a decrease in white blood cells, it is advisable to promptly visit a hospital for an examination to check for lupus. Some patients may also experience Raynaud's phenomenon and photosensitivity in the early stages of lupus. There are no fixed symptoms in the early stages of lupus; it is mainly important to observe oneself regularly and seek medical attention if feeling unwell.

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Written by Liu Li Ning
Rheumatology
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Where does lupus erythematosus generally appear?

Lupus erythematosus can appear on various parts of the body. The most typical rash is the butterfly rash on the face, but it can also appear on other parts, such as discoid lupus, annular erythema, periungual erythema, and livedo reticularis. Additionally, systemic lupus erythematosus affects not only the skin and mucosa but can also involve the lungs, kidneys, heart, central nervous system, and other systems. Common manifestations include lupus nephritis and lupus pneumonia. The precise pathogenesis of systemic lupus erythematosus is still unclear. If the damage is confined to the skin and mucosa, immunomodulators such as hydroxychloroquine can be used for treatment. If important organs are involved, it generally requires long-term maintenance treatment with corticosteroids combined with immunosuppressants to control the progression of the disease.

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Written by Zhang Lin
Rheumatology and Immunology Nephrology
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What causes lupus erythematosus?

The cause of lupus erythematosus is not yet very clear. It is generally believed that the disease is caused by a combination of factors including genetics, environment, estrogen levels, and drugs, leading to immune disorder and consequently the onset of this disease. Studies have found that factors directly related to the onset of lupus erythematosus include ultraviolet rays causing apoptosis of epidermal cells, exposure of new antigens becoming autoantigens, and infections; Other possible related factors include drugs such as hydralazine and isoniazid, as well as food dyes, hair dyes, celery, figs, mushrooms, smoked foods, psychological stress, etc.; it may also be related to factors such as tobacco, vinyl chloride, asbestos, and vaccinations.