What causes lupus erythematosus?

Written by Li Jing
Rheumatology
Updated on April 28, 2025
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Firstly, systemic lupus erythematosus is a chronic, multi-systemic, systemic autoimmune disease that commonly occurs in women of childbearing age, more frequently seen in females, with a significantly higher incidence rate in females than in males. The cause is currently unclear, only indicating that experts believe it is related to environmental pollution, viral infections, hormone levels, genetics, etc., but there is no definitive evidence proving which factors it is related to, only stating that there are studies linking it to these factors. Its clinical manifestations also vary, with most cases having a gradual onset, characterized by recurrent erythema, even pustules, Raynaud's phenomenon, etc. A minority of patients may have a sudden onset, primarily presenting with major hematologic damage.

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Written by Liu Li Ning
Rheumatology
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Does lupus erythematosus transmit through living and eating together?

Lupus erythematosus is not contagious through sharing meals or living together. It is an autoimmune disease, not an infectious one, hence it cannot be transmitted to others by living or eating together. The exact mechanism of lupus is currently unclear, but it may be related to various factors such as sex hormones, genetics, infections, and physical and chemical factors, and it is more commonly seen in females. Clinically common symptoms include fever, rash, joint pain, oral ulcers, hair loss, etc. The clinical manifestations vary depending on the affected target organ. If lupus nephritis occurs, symptoms such as edema can appear. If the lungs are involved, it can promote pulmonary interstitial fibrosis, and in severe cases, patients may experience chest tightness, shortness of breath, and breathing difficulties.

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home-news-image
Written by Li Jing
Rheumatology
55sec home-news-image

What causes lupus erythematosus?

Firstly, systemic lupus erythematosus is a chronic, multi-systemic, systemic autoimmune disease that commonly occurs in women of childbearing age, more frequently seen in females, with a significantly higher incidence rate in females than in males. The cause is currently unclear, only indicating that experts believe it is related to environmental pollution, viral infections, hormone levels, genetics, etc., but there is no definitive evidence proving which factors it is related to, only stating that there are studies linking it to these factors. Its clinical manifestations also vary, with most cases having a gradual onset, characterized by recurrent erythema, even pustules, Raynaud's phenomenon, etc. A minority of patients may have a sudden onset, primarily presenting with major hematologic damage.

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Written by Liu Li Ning
Rheumatology
59sec home-news-image

What does the early rash of lupus look like?

The early characteristic rash of lupus erythematosus is typically a butterfly-shaped rash on the face. Other common presentations include palm and periungual erythema, discoid rash, nodular erythema, and livedo reticularis. If the rash is not notably itchy, it generally indicates lupus erythematosus. If there is significant itching, it may suggest the possibility of an allergic factor active in the disease. After immunosuppression, itchy rashes should be monitored for possible fungal infections. The specific pathogenesis of systemic lupus erythematosus is still unclear. If a patient exhibits the typical butterfly-shaped rash on the face, systemic lupus erythematosus should be highly suspected. Testing for antinuclear antibodies, and specifically for anti-Sm and double-stranded DNA antibodies, which represent a variety of autoantibodies, can diagnose systemic lupus erythematosus.

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Written by Zhang Lin
Rheumatology and Immunology Nephrology
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What are the symptoms of the early stage of lupus erythematosus?

The main symptom in the early stage of lupus is the appearance of a butterfly-shaped rash on the face, with most patients initially exhibiting these rashes, some of which are not butterfly-shaped. The rash can also appear on fingers, palms, and around the nails. Additionally, over 80% of patients experience unexplained fevers, which are irregular and can sometimes reach up to 40 degrees Celsius. Some patients also experience joint pain in the early stages of the disease, mainly starting with pain in larger joints such as the elbows, knees, and ankles. If joint pain is accompanied by fever, rash, and a decrease in white blood cells, it is advisable to promptly visit a hospital for an examination to check for lupus. Some patients may also experience Raynaud's phenomenon and photosensitivity in the early stages of lupus. There are no fixed symptoms in the early stages of lupus; it is mainly important to observe oneself regularly and seek medical attention if feeling unwell.

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Written by Zhang Lin
Rheumatology and Immunology Nephrology
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What are the symptoms of a lupus flare-up?

After treatment with steroids and other therapies, active lupus erythematosus usually improves and enters a stable phase. However, factors such as infection, pregnancy, surgery, fatigue, and discontinuation of medication can trigger the transition from a stable phase back to an active phase of lupus erythematosus. The following symptoms should be considered for a possible recurrence of the disease: First, onset of fever without reasons related to colds or infections. Second, appearance of new rashes or vascular-like rashes on fingertips and other areas. Third, recurrence of joint swelling and pain. Fourth, significant hair loss. Fifth, development of fresh ulcers in the mouth or nose. Sixth, development of fluid accumulation in the chest cavity or pericardium. Seventh, increased protein in urine, decrease in white blood cells or platelets, or significant anemia.