How is malignant lymphoma treated?

Written by Peng Li Bo
Oncology
Updated on January 16, 2025
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The common treatments for malignant lymphoma currently include chemotherapy, targeted therapy, radiation therapy, and the use of immunosuppressants. There are also newer treatments such as cell reinfusion. The choice of treatment for malignant lymphoma definitely depends on the specific pathological type. Another factor is the stage of the lymphoma—it could be in stages one, two, three, or four, which definitely matters. The third factor is whether the lymphoma causes any symptoms or signs in the patient because some minor lymphomas may allow for observation and waiting, but many require active treatment.

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Written by Liu Liang
Oncology
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What is lymphoma?

Lymphoma refers to a type of malignant tumor that originates in the lymph nodes or extranodal tissues or organs. It is clinically categorized into two main types: Hodgkin's lymphoma and non-Hodgkin's lymphoma. Furthermore, it can be subdivided into many different pathological types. Among these, diffuse large B-cell lymphoma is the most common type in China, and there are dozens of different pathological types. The pathological type of the lymphoma determines its malignancy level, prognosis, chemotherapy regimen options, and treatment methods, all of which can vary significantly.

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Written by Peng Li Bo
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What are the symptoms of lymphoma?

The symptoms of lymphoma usually involve painless, progressive enlargement of the lymph nodes, typically located in areas like the neck, under the jaw, and below the chin. However, beyond these localized symptoms, lymphoma can also present with systemic symptoms, which include fever, night sweats, weight loss, as well as rashes and itching skin. Thus, lymphoma encompasses both local and systemic symptoms.

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Written by Liu Liang
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The pattern of fever in lymphoma

Fever symptoms are quite common in patients with lymphoma, which we refer to as B symptoms. The pattern of their fevers is primarily low-grade, occurring more frequently in the afternoon or evening. Unlike ordinary bacterial infections, fevers in these patients do not respond well to anti-inflammatory drugs, but they do respond better to steroid treatment for reducing fever. However, if the lymphoma is not under control, their fever will repeatedly recur. Corresponding cooling treatments can reduce the temperature, but the fever will reoccur repeatedly. Only when the lymphoma and tumor are under control will the fever symptoms start to improve.

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Written by Liu Liang
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What are the symptoms of lymphoma?

The symptoms of lymphoma predominantly start with painless enlargement of superficial lymph nodes, most commonly in areas such as the neck, supraclavicular lymph nodes, armpits, or groin. Additionally, patients with nasal NKT lymphoma might experience nasal congestion, nosebleeds, and rhinorrhea. Lymphomas occurring in the stomach, for example, present symptoms like nausea, vomiting, and even rectal bleeding which are related to the gastrointestinal tract. Therefore, symptoms can vary depending on the location of the lymphoma. Some patients may also experience enlargement of the liver and spleen. In advanced stages of lymphoma, bone marrow involvement is possible, along with common B symptoms including sweating, fever, or weight loss, which are also clinical manifestations seen in lymphoma patients.

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Written by Peng Li Bo
Oncology
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Is lymphoma hereditary?

Lymphoma is generally not hereditary, as it is not a genetic disease. However, I must mention that most neoplastic diseases do have some hereditary factors to some extent. The reason for this is that the cause of lymphoma is currently unclear, and it may be related to genetic mutations, which raises the issue of heredity. Another point is that heredity often refers to transmission among direct relatives. This means there could be a problem in that you might share similar environments and lifestyles, including diet. If there are factors in your diet or living environment that could trigger lymphoma, and you are both exposed to these factors, then your probability of developing lymphoma could indeed be higher than in patients without a family history, leading to such a concern.