What is lymphoma?

Written by Liu Liang
Oncology
Updated on September 08, 2024
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Lymphoma refers to a type of malignant tumor that originates in the lymph nodes or extranodal tissues or organs. It is clinically categorized into two main types: Hodgkin's lymphoma and non-Hodgkin's lymphoma. Furthermore, it can be subdivided into many different pathological types. Among these, diffuse large B-cell lymphoma is the most common type in China, and there are dozens of different pathological types. The pathological type of the lymphoma determines its malignancy level, prognosis, chemotherapy regimen options, and treatment methods, all of which can vary significantly.

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Written by Liu Liang
Oncology
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Is lymphoma the same as lymphatic cancer?

Lymphoma refers to a type of malignant tumor that originates in lymph nodes or extranodal tissues or organs. The cancer we usually talk about refers to malignant tumors originating from epithelial tissues, which we call cancer, such as lung cancer, liver cancer, etc. Therefore, lymphoma is actually what non-medical professionals commonly refer to as lymphatic cancer. It is simply called lymphoma instead of cancer because it originates in lymph nodes or extranodal tissues or organs, and therefore, it is termed malignant lymphoma, which in layman's terms is lymphatic cancer.

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Written by Peng Li Bo
Oncology
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Is lymphoma hereditary?

Lymphoma is generally not hereditary, as it is not a genetic disease. However, I must mention that most neoplastic diseases do have some hereditary factors to some extent. The reason for this is that the cause of lymphoma is currently unclear, and it may be related to genetic mutations, which raises the issue of heredity. Another point is that heredity often refers to transmission among direct relatives. This means there could be a problem in that you might share similar environments and lifestyles, including diet. If there are factors in your diet or living environment that could trigger lymphoma, and you are both exposed to these factors, then your probability of developing lymphoma could indeed be higher than in patients without a family history, leading to such a concern.

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Written by Peng Li Bo
Oncology
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Early symptoms of lymphoma

The early symptoms of lymphoma involve the painless enlargement of both superficial and deep lymph nodes, most commonly located in areas such as the neck, armpits, and groin. Of course, lymphoma also presents with systemic symptoms, such as fever, night sweats, weight loss, and skin itching. Since lymphoma commonly occurs in the neck, armpits, and groin, if it develops in other areas, such as the lungs or elsewhere, it may cause respiratory symptoms, including coughing, expectoration, and shortness of breath.

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Written by Zhou Chen
Oncology
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What to check for malignant lymphoma?

The examination of lymphoma first requires routine blood tests and blood smears. When aggressive lymphoma invades the bone marrow, anemia, decreased white blood cells, and platelets may occur, and lymphoma cells can appear in peripheral blood; therefore, bone marrow smears and biopsies are necessary. Additionally, blood biochemistry is important, as an increase in lactate dehydrogenase is associated with tumor burden and is an indicator of poor prognosis. Furthermore, Hodgkin's lymphoma may involve the central nervous system, so patients with symptoms of central nervous system involvement need to undergo cerebrospinal fluid examination. The most important aspect of lymphoma is the histopathological examination. Based on the histopathological examination, the pathological staging is determined, and genetic rearrangement can also be performed.

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Written by Peng Li Bo
Oncology
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Causes of Malignant Lymphoma

Currently, the causes of lymphoma are not clear. It may be related to genetic mutations, infections, pathogens, or other viruses. Additionally, exposure to radiation or chemical drugs, and its association with autoimmune diseases, are also relevant factors. Clinically, there are specific types of lymphoma, such as mucosa-associated lymphoma related to the stomach lining, which is notably associated with Helicobacter pylori infections. Another type is related to infection with the Epstein-Barr virus.