Lymphoma occurs in which part?

Written by Liu Liang
Oncology
Updated on May 18, 2025
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Lymphoma can develop in many different parts of the body and lymph nodes, with the most common being the enlargement of superficial lymph nodes, such as those in the neck, armpits, and groin. The pharyngeal lymphatic ring, including places like the oropharynx, base of the tongue, and tonsils, also commonly exhibit lymph node enlargement in cases of lymphoma. Additionally, lymphoma frequently occurs in the nasal cavity and the mediastinum in the chest, as well as in the abdomen, including lymphomas of the gastrointestinal tract and primary lymphomas of the liver and spleen, and even the retroperitoneal mesentery and pelvic lymph nodes. The skin and bone marrow can also be primary sites for lymphoma. Thus, it can affect multiple parts of the body, with many areas being susceptible to lymphoma.

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Oncology
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Symptoms of Lymphoma

The symptoms of lymphoma mostly present as painless enlarged superficial lymph nodes, which are common clinical manifestations. Additionally, there may be enlargement of the liver and spleen, with multiple organs throughout the body possibly affected. In advanced stages, patients may experience invasion of the bone marrow. There are also special types of extranodal lymphomas which exhibit specific symptoms. For instance, lymphomas originating in the stomach may present with upper abdominal masses, or symptoms like anemia, weight loss, black stools, and even upper abdominal pain, nausea, and vomiting related to the gastrointestinal tract. If the lymphoma originates in the nasal cavity, known as NK/T-cell lymphoma, symptoms may include tinnitus, nasal congestion, runny nose, and nosebleeds, among others. Some lymphoma patients may also experience fever, generalized weakness, weight loss, collectively referred to as B symptoms.

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Lymphoma has what manifestations?

The symptoms of lymphoma, simply put, are that some people feel a lump on their neck or in their armpit; it starts as a sudden appearance of a swelling that gets larger over time, sometimes not just one, but multiple lumps clustered together. This is indeed the most common symptom, where one can feel something on their neck, including under the jaw or the chin, noticing suddenly a nodule has formed, whether it's the size of a chicken egg or otherwise. That's one aspect. The second involves systemic symptoms, which primarily include fever, night sweats, and weight loss. These three symptoms are quite common.

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What are the symptoms of lymphoma spread?

The symptoms of lymphoma spread depend primarily on its original location. Generally, the most common site of origin is in the neck. Spread means that it has moved to other areas, so it may have spread to the armpits, groin, or popliteal fossa. If there is swelling or a tumor in the lymph nodes in these areas, it manifests as a tumor that can be felt in those specific locations, like in the groin or armpits. Of course, it is possible that it may spread to substantive organs, such as the lungs. If it spreads to the lungs, symptoms might include shortness of breath, coughing, and blood in the sputum.

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Causes of Malignant Lymphoma

The causes of malignant lymphoma are the result of multiple factors. First, it is associated with infections by bacteria or viruses, such as the well-documented chronic infection with Helicobacter pylori, which is closely related to the occurrence of lymphoma associated with the gastric mucosa. Second, immunodeficiency conditions, like in AIDS patients or those who have been taking immunosuppressive drugs for a long period, have a higher likelihood of developing malignant lymphoma compared to the general population. Third, chemical or physical factors, such as environmental carcinogens and electromagnetic radiation, can also lead to malignant lymphoma. Other factors, such as long-term use of certain drugs like phenytoin or pseudoephedrine, and a genetic predisposition, can also be causes of malignant lymphoma.

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Lymphoma registration: which department?

Patients diagnosed with lymphoma can register under the departments of Hematology or Oncology, as both departments can administer chemotherapy. However, radiation therapy can only be conducted in the Oncology department. Each hospital may have slightly different categorizations for departments and diseases. However, for a patient initially presenting with lymphoma, who has not yet been diagnosed and primarily shows symptoms of painless lymph node enlargement, they can register under General Surgery. After completing necessary examinations like an ultrasound, if lymphoma is suspected, a lymph node excision biopsy is usually performed in General Surgery.