The symptoms of lymphoma spread depend primarily on its original location. Generally, the most common site of origin is in the neck. Spread means that it has moved to other areas, so it may have spread to the armpits, groin, or popliteal fossa. If there is swelling or a tumor in the lymph nodes in these areas, it manifests as a tumor that can be felt in those specific locations, like in the groin or armpits. Of course, it is possible that it may spread to substantive organs, such as the lungs. If it spreads to the lungs, symptoms might include shortness of breath, coughing, and blood in the sputum.