Symptoms of hand, foot, and mouth disease

Written by Quan Xiang Mei
Pediatrics
Updated on May 20, 2025
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Hand, foot, and mouth disease is a common infectious disease during childhood, characterized by rashes on the hands, feet, and around the mouth as described by its clinical symptoms. Concurrently, with the red rashes, there are symptoms such as fever. In children, vesicles in the throat can cause severe sore throat. These are the common symptoms of hand, foot, and mouth disease. Since hand, foot, and mouth disease is caused by a viral infection, some children may experience myocarditis-like symptoms such as chest tightness, fatigue, and shortness of breath due to the virus affecting the myocardium, or present symptoms of myocardial damage. These are common clinical symptoms of hand, foot, and mouth disease.

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Written by Yan Xin Liang
Pediatrics
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How many days does hand, foot and mouth disease have a fever?

Hand, foot, and mouth disease is caused by an intestinal virus infection and is characterized by acute fever and vesicles or papules on the hands, feet, mouth, buttocks, and other areas. There are more than 20 types of enteroviruses that cause this disease, with the most common being Enterovirus 71 and Coxsackievirus A16. In typical cases, the fever may last about two to three days, but there are also cases with mild symptoms where no fever appears, or only a low fever occurs, lasting one to two days. In severe cases, the fever may last longer, from three to five days or even more. Therefore, it can only be said that in most cases, the fever in typical cases may last about two to three days.

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Written by Yan Xin Liang
Pediatrics
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Symptoms of hand, foot, and mouth disease

Hand, foot, and mouth disease is a disease caused by enterovirus that results in sores on the hands, feet, mouth, and buttocks, accompanied by symptoms such as fever. It is generally caused by Enterovirus 71 or Coxsackievirus A16. Most cases of hand, foot, and mouth disease are typical and may involve fever, low fever, or no fever at all. However, common symptoms include sores in the mouth and on the pharynx, as well as on the hands, feet, and buttocks. The general course of the disease lasts five to seven days, but severe cases may last longer. Severe cases may present with symptoms such as listlessness, irritability, vomiting, and trembling limbs. More serious conditions can include microcirculatory disorders, difficulty breathing, shortness of breath, neurogenic edema, and bleeding, among others.

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Written by Yao Li Qin
Pediatrics
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Initial symptoms of hand, foot, and mouth disease

Hand, foot, and mouth disease is a common pediatric exanthematous disease caused by an enterovirus infection, primarily manifesting on the hands, feet, mouth, and buttocks with scattered vesicular and pustular rashes. The incubation period for hand, foot, and mouth disease generally ranges from three to five days. The initial stage of the illness may include fever and sore mouth, or discomfort in the throat, leading to reluctance in children to eat. Accompanying symptoms might include mild coughing, runny nose, and throat discomfort. During a physical examination, a doctor may observe scattered small vesicles in the mouth mucosa, or shallow ulcers that have already erupted. These are mainly found on the lingual and buccal mucosa, as well as the mucosa on the inner side of the lips and upper palate. Subsequently, rashes appear on the hands and feet, generally starting as maculopapular rashes that slowly turn into vesicular rashes. These rashes are distributed eccentrically and typically resolve on their own within two to three days without scaling, scarring, or pigmentation. The oral vesicles usually heal on their own within a week. Some children with milder cases may only exhibit rashes or vesicular pharyngitis.

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Written by Yao Li Qin
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Hand, foot, and mouth disease transmission routes

Hand, foot, and mouth disease is caused by an intestinal virus infection, characterized by a rash of scattered maculopapular and vesicular lesions on the hands, feet, mouth, and buttocks. Generally, the prognosis is good. The disease is quite contagious, primarily spreading through the gastrointestinal tract, respiratory tract, and close contact. Therefore, during peak seasons of hand, foot, and mouth disease, children should stay at home and avoid crowded places and playing with children who have the disease. The highest incidence of this disease is among children under three years old, so it is essential to pay attention to the prevention and health care of infants. If a child in kindergarten is found to have the disease, they should rest at home and not return to the kindergarten immediately.

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Causes of Hand, Foot, and Mouth Disease

Hand, foot, and mouth disease is a rash illness characterized by scattered papules and vesicles on the hands, feet, mouth, and buttocks, caused by an enterovirus infection. It is a contagious disease caused by a viral infection, specifically by Coxsackievirus A16 and Enterovirus 71, which are part of the enterovirus group. Other Coxsackie enteroviruses can also cause hand, foot, and mouth disease. Common enterovirus infections can also lead to hand, foot, and mouth disease. This means that children who have had hand, foot, and mouth disease can potentially get it again, and this is important knowledge for everyone to understand.