Symptoms of hand, foot, and mouth disease

Written by Quan Xiang Mei
Pediatrics
Updated on May 20, 2025
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Hand, foot, and mouth disease is a common infectious disease during childhood, characterized by rashes on the hands, feet, and around the mouth as described by its clinical symptoms. Concurrently, with the red rashes, there are symptoms such as fever. In children, vesicles in the throat can cause severe sore throat. These are the common symptoms of hand, foot, and mouth disease. Since hand, foot, and mouth disease is caused by a viral infection, some children may experience myocarditis-like symptoms such as chest tightness, fatigue, and shortness of breath due to the virus affecting the myocardium, or present symptoms of myocardial damage. These are common clinical symptoms of hand, foot, and mouth disease.

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Written by Yao Li Qin
Pediatrics
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Is hand, foot, and mouth disease serious?

Hand, foot, and mouth disease is a contagious viral infection primarily characterized by scattered vesicular or papular rashes on the hands, feet, mouth, and buttocks. It is generally a mild condition, and typical symptoms include fever and rash. It can be treated with oral medications and by taking care of oral and skin hygiene, usually healing quickly. Severe cases caused by the EV71 virus can lead to varying degrees of intracranial pressure. In such serious cases, prompt treatment with mannitol and furosemide to reduce intracranial pressure is necessary; corticosteroids may also be needed if required. For children with severe hypoxia, timely correction of oxygen deficiency is crucial, along with intravenous fluids to maintain stable blood pressure, respiration, heart rate, and microcirculation. (Please consult a professional physician for medication guidance and do not self-medicate.)

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Written by Yan Xin Liang
Pediatrics
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Is hand, foot and mouth disease itchy?

Hand, foot and mouth disease is an infectious disease caused by enteroviruses. There are more than 20 types of enteroviruses that cause hand, foot and mouth disease, among which Coxsackievirus A16 and Enterovirus 71 are the most common. Its main clinical symptoms include mouth pain, decreased appetite, mild fever, and the appearance of small vesicles or small ulcers on the hands, feet, mouth, and other areas. Most infected children can recover in about a week. The rash of hand, foot and mouth disease typically appears on the hands, feet, buttocks, arms, and legs as maculopapular rash, which can later turn into vesicles. These vesicles are surrounded by an inflammatory red halo and contain relatively little fluid. The rash is not itchy. Thus, the rash of hand, foot and mouth disease is unlike other allergic rashes; it does not cause itching or discomfort.

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Written by Yao Li Qin
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Hand, foot and mouth disease characteristics

Hand, foot, and mouth disease is an infectious disease caused by enterovirus, primarily characterized by scattered maculopapular or vesicular rashes on the hands, feet, mouth, and buttocks. These rashes are quite distinctive; initially, there is a fever, followed by rashes on hands and feet. These are commonly found between the fingers, starting as maculopapular rashes and gradually turning into vesicular rashes. The rashes, measuring three to seven millimeters, have a firm base with slightly thickened skin over the blisters and are surrounded by erythema. They occur mainly on the extremities but can sometimes spread to the arms, legs, buttocks, or perineal area. The distribution of the rash is centrifugal, ranging from a few to dozens in number. Generally, the rashes absorb on their own within two to three days without scaling, scarring, or pigmentation, and oral blisters or ulcers usually heal within a week.

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Written by Yao Li Qin
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Does hand, foot, and mouth disease cause fever?

Hand, foot, and mouth disease is a contagious childhood exanthem caused by an intestinal virus infection. The primary symptoms of most hand, foot, and mouth diseases include fever, followed by rashes on the hands, feet, mouth, and buttocks, as well as vesicles in the throat. However, not all children with the disease necessarily experience continuous fever or any fever at all. Some only show symptoms after coming into contact with an infected person, with rashes on the hands, feet, mouth, and buttocks, and vesicles in the throat. In such cases, it is still considered hand, foot, and mouth disease, and fever is not a requisite for diagnosis. Thus, the presence of fever should not be solely relied upon for diagnosing the disease.

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Written by Yan Xin Liang
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Does hand, foot and mouth disease hurt?

Hand, foot, and mouth disease is caused by an intestinal virus, mainly manifested in children as blisters on the hands, feet, mouth, and buttocks. Some cases may involve fever, while others may have no fever or only mild, low-grade fever. Oral and pharyngeal blisters are quite common, causing oral pain and discomfort. Many children who contract hand, foot, and mouth disease experience a decrease in appetite, which is related to oral and pharyngeal blisters causing pain that affects swallowing and eating.