Hand, foot, and mouth disease is an infectious disease caused by enterovirus, primarily characterized by scattered maculopapular or vesicular rashes on the hands, feet, mouth, and buttocks. These rashes are quite distinctive; initially, there is a fever, followed by rashes on hands and feet. These are commonly found between the fingers, starting as maculopapular rashes and gradually turning into vesicular rashes. The rashes, measuring three to seven millimeters, have a firm base with slightly thickened skin over the blisters and are surrounded by erythema. They occur mainly on the extremities but can sometimes spread to the arms, legs, buttocks, or perineal area. The distribution of the rash is centrifugal, ranging from a few to dozens in number. Generally, the rashes absorb on their own within two to three days without scaling, scarring, or pigmentation, and oral blisters or ulcers usually heal within a week.