Hand, foot, and mouth disease is a disease caused by enterovirus that results in sores on the hands, feet, mouth, and buttocks, accompanied by symptoms such as fever. It is generally caused by Enterovirus 71 or Coxsackievirus A16. Most cases of hand, foot, and mouth disease are typical and may involve fever, low fever, or no fever at all. However, common symptoms include sores in the mouth and on the pharynx, as well as on the hands, feet, and buttocks. The general course of the disease lasts five to seven days, but severe cases may last longer. Severe cases may present with symptoms such as listlessness, irritability, vomiting, and trembling limbs. More serious conditions can include microcirculatory disorders, difficulty breathing, shortness of breath, neurogenic edema, and bleeding, among others.