Ovarian Cancer Screening Methods

Written by Liu Liang
Oncology
Updated on September 10, 2024
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The methods for diagnosing ovarian cancer include imaging studies, such as ultrasonography of the adnexa of the uterus, abdominal CT, or MRI, which can detect ovarian tumors. The next step is to perform a blood test for the tumor marker CA125, which is a relatively specific and sensitive marker for epithelial ovarian cancer; in clinical practice, CA125 levels are generally significantly elevated in patients with ovarian cancer. Additionally, many patients with ovarian cancer, especially those in advanced stages, often develop significant ascites. We can perform abdominal paracentesis to drain the fluid and test the ascites for cancer cells. If cancer cells are found in the ascites and imaging studies reveal an ovarian mass, ovarian cancer can be diagnosed. Furthermore, chest CT and other tests are included to comprehensively assess the staging of the patient.

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Written by Liu Liang
Oncology
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Is ovarian cancer hereditary?

The onset of ovarian cancer may be somewhat related to family history or genetic factors. Therefore, patients with a family history of ovarian cancer may have a higher risk of developing the disease compared to the general population. However, this doesn't mean that a patient with ovarian cancer will definitely pass the condition to their offspring; it merely indicates a certain level of heredity. Furthermore, for those with a family history of breast cancer, colon cancer, and endometrial cancer, it is crucial for their descendants to undergo enhanced screenings for ovarian cancer and these diseases, as their risk of developing these conditions may be higher than that of the average person.

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Written by Liu Liang
Oncology
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Can ovarian cancer be detected by transvaginal ultrasound?

Ovarian cancer can generally be detected through a transvaginal ultrasound. During this procedure, we can find cystic or cystic-solid, or a solid mass in the ovaries. If a blood test for tumor markers shows a significant increase in CA125, especially in combination with a large amount of ascites, we must strongly suspect ovarian cancer. In such cases, patients should undergo a tumor biopsy. By taking a biopsy and confirming it pathologically, we can definitively diagnose ovarian cancer. Therefore, most ovarian cancer patients can indeed be detected through a transvaginal ultrasound.

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Written by Liu Liang
Oncology
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Ovarian cancer stage IC means

If it is stage Ic ovarian cancer, it refers to the tumor being confined to one or both ovaries, without involvement of other pelvic organs or distant organs such as the liver or lungs. However, it must meet any of the following conditions: the first is the rupture of the capsule with tumor on the surface; the second is the presence of cancer cells in the ascites or peritoneal lavage fluid. Meeting any of these conditions, along with the tumor being limited to one or both ovaries, classifies it as stage Ic.

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Written by Yan Chun
Oncology
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What are the early symptoms of ovarian cancer?

The early symptoms of ovarian cancer are not severe or common clinically. Some patients may experience abdominal distension and pain. Some may have menstrual irregularities, such as prolonged or shortened menstrual cycles, increased menstrual flow, or irregular bleeding outside of menstruation. Additionally, a small number of patients may experience pelvic pain due to local tumor compression caused by ovarian cancer. This pain occasionally radiates to the perineal area and is generally mild, rarely affecting the patient's quality of life. Furthermore, a minor proportion of ovarian cancer patients, particularly those with tumors having endocrine functions, may exhibit symptoms associated with paraneoplastic syndromes.

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Written by Liu Liang
Oncology
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ovarian cancer specific drug

Ovarian cancer does not have any specific cure-all treatment. Most ovarian cancers are epithelial ovarian cancers, and there is also ovarian cancer resulting from malignant germ cells, which is a rarer pathology type. For epithelial ovarian cancer, treatment methods include surgery, radiation therapy, chemotherapy, and some targeted therapies, mainly using Bevacizumab, which is a monoclonal antibody that inhibits angiogenesis, and is usually used in combination with chemotherapy drugs. For patients with advanced ovarian cancer, those who are resistant to chemotherapy, or those in poor general health unable to endure chemotherapy, palliative treatments like hormone treatment using progestogens are an option, along with immune therapy being available nowadays. Surgery is primarily for early-stage ovarian cancer patients, where curative surgical resection is possible, or for debulking surgery in patients with advanced ovarian cancer. Chemotherapy is frequently used as it is relatively effective for epithelial ovarian cancer, a type of cancer that is somewhat sensitive to such treatments. The drugs used mainly include taxane combined with platinum-based chemotherapy. For intravenous administration or intraperitoneal delivery—for the latter, mainly for ovarian cancers complicated by extensive ascites—, positioning an abdominal drainage tube and then infusing platinum-based chemotherapy drugs into the abdominal cavity are utilized.