The symptoms of syphilis in men are divided into three stages, depending on the condition of the disease. The most common symptom of primary syphilis is a chancre. It is usually seen on the glans, coronal sulcus, foreskin, and frenulum of the penis as small red spots, which quickly develop into painless inflammatory papules. After several days, the papules can enlarge and form a hard lump with serous secretions on the surface. Secondary syphilis generally occurs due to incomplete treatment of primary syphilis, or lack of timely treatment, leading to damage on the skin and mucous membranes, such as flat condyloma and maculopapular syphilitic rash. Tertiary syphilis usually appears two to three years after the syphilis infection. Patients can exhibit skin and mucous membrane damage, mainly nodular syphilitic rash and gummatous syphilis.