Syphilis is a chronic, systemic sexually transmitted disease caused by the Treponema pallidum bacterium. It is highly contagious and very harmful. The early symptoms of syphilis usually include the appearance of a chancre. Typically, about three weeks after infection, a hard, painless, round nodule appears at the site of infection. It starts as a reddish, moist spot, then gradually becomes ulcerated and eroded, forming an ulcer. This is an early manifestation of syphilis, known as a chancre. The harm caused by syphilis is very significant. Once syphilis is diagnosed, it is crucial to start treatment early. Early prevention of syphilis is essential, and any early symptoms should be taken very seriously. Treatment can be administered under a doctor's guidance, usually involving the muscle injection of long-acting penicillin. (Under the guidance of a doctor for medication.)