Secondary syphilis generally occurs three to four weeks after the disappearance of the primary chancre, which means it often occurs 9 to 12 weeks after the infection by the Treponema pallidum. Of course, it is rare yet possible for it to appear simultaneously with the primary chancre. The main reason secondary syphilis develops is either due to untreated primary syphilis or incomplete treatment. The Treponema pallidum enters the bloodstream from the lymphatic system, causing bacteremia and spreading throughout the body, leading to systemic damage including skin and mucosal lesions, known as secondary syphilis. Common signs of secondary syphilis include erythema on the palms and soles, which is a characteristic manifestation. Another sign includes flat, moist warts around the anus and genital areas, similar to condyloma acuminatum, but these warts are flatter and less protruding.