Tertiary syphilis is the most severe stage of syphilis. The most common skin and mucosal damage in tertiary syphilis appears on the scalp, scapula, back, and the extensor sides of the limbs, where nodular syphilitic rashes can be observed, and gummatous swellings can also be seen on the lower legs. Apart from damaging the skin and mucous membranes, tertiary syphilis can also harm the cardiovascular and nervous systems. If the cardiovascular system is affected, it can cause problems in the aortic arch, leading to aortic valve insufficiency and syphilitic heart disease. If the nervous system is involved, it can cause neurosyphilis, manifesting as syphilitic meningitis, cerebrovascular syphilis, meningeal gumma, paralytic dementia, and more. In summary, once afflicted with tertiary syphilis, patients can exhibit a variety of clinical symptoms such as increased intracranial pressure, headaches, sensory abnormalities, ataxia, paralytic dementia, and localized brain compression, among other symptoms.