Syphilis IgM negative, which is primarily screened using the ELISA method. Generally, a negative IgM can temporarily rule out syphilis. If still uncertain, further confirmatory syphilis tests can be conducted, such as TPPA (Treponema Pallidum Particle Agglutination) or TPHA (Treponema Pallidum Hemagglutination). Usually, syphilis can be temporarily dismissed if IgM is negative. However, if symptoms of a primary chancre are present, such as genital ulcers, an early Syphilis IgM might be negative. In such cases where symptoms are clear but IgM is negative, it is typically advised to retest after one month. If the result turns positive, a confirmatory test should be performed to diagnose and treat syphilis.