Is third-stage syphilis contagious?

Written by Zhu Zhu

Dermatology

Updated on January 27, 2025

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Third-stage syphilis is infectious, but its contagiousness is relatively weak compared to first-stage and second-stage syphilis. The titers detected in third-stage syphilis are usually lower, so its infectiousness is comparatively minor. However, third-stage syphilis still has the capability to infect others. Therefore, patients with third-stage syphilis must actively seek treatment and refrain from having sexual relations with others, while also enhancing their own immunity.

Other Voices

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Written by Li Chang Yue

General Surgery

1min 1sec

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Is there a high possibility of syphilis with enlarged inguinal lymph nodes?

Enlarged inguinal lymph nodes generally suggest the possibility of syphilis, but such enlargement caused by syphilis commonly appears in the secondary or tertiary stages of the disease. In the early primary stage of syphilis, it is rare to see swollen inguinal lymph nodes; the symptoms are mostly seen on the external genitals, including soft and hard chancres. As syphilis progresses, it may gradually lead to swelling of the inguinal lymph nodes, including other superficial lymph nodes. However, enlargement of the inguinal lymph nodes alone cannot conclusively determine that the cause is syphilis. Other conditions such as bacterial lymphadenitis, lymph node tuberculosis, or lymphoma could also cause swollen inguinal lymph nodes. Therefore, to diagnose whether it is caused by syphilis, it is crucial to consider the results of syphilis serological tests and specific pathological puncture findings.

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Written by Zhai Yu Juan

Dermatology Department

38sec

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Is syphilis contagious?

Syphilis is a sexually transmitted disease caused by infection with the syphilis spirochete. After infection, the pathogen can invade various organs throughout the body, causing a variety of symptoms. As a classic sexually transmitted disease, syphilis is contagious, with its main routes of transmission being through sexual contact, mother-to-child transmission, and also through close contact, such as kissing, or the use of daily items from a syphilis patient, such as towels, razors, cutlery, etc. If syphilis is not treated, its infectivity gradually decreases over time.

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Written by Luo Hong

Dermatology Department

52sec

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Can syphilis antibodies be detected during the hard chancre stage?

During the hard chancre phase of syphilis, a portion of cases can test positive for Treponema pallidum, although some tests may return negative results. In such cases, it is advisable to retest after one month. The earliest detectable antibodies for Treponema pallidum are usually of two types: a Treponema pallidum-specific antibody, which appears earlier than the non-specific antibodies. There are tests for non-specific antibodies, commonly referred to as RPR or TRUST, which are standard practices in major hospitals. Therefore, in early-stage syphilis or primary syphilis with hard chancre, it is possible to find Treponema pallidum-specific antibodies positive, RPR or TRUST negative, or both negative. If syphilis is strongly suspected in such cases, a retest is recommended after one month.

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Written by Zhu Zhu

Dermatology

33sec

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Will third-stage syphilis be asymptomatic?

In the case of third-stage syphilis, it is generally not asymptomatic, as it is already a late stage of the disease that invades multiple systems, such as the musculoskeletal system, nervous system, and even the cardiovascular system. When these systems are invaded, they become damaged, leading to various complications. Therefore, third-stage syphilis typically presents with various signs of organ dysfunction, and it is unlikely to be without any symptoms once it has progressed to this stage.

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Written by Zhu Zhu

Dermatology

41sec

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Can third-stage syphilis be cured?

Third-stage syphilis can potentially be fatal, but this is not absolute. With proper and timely treatment, it can gradually improve. Third-stage syphilis is the most severe and latest stage of the disease, also known as late-stage syphilis. This stage often affects our skin, bones, cardiovascular system, and even the nervous system. When these systems are affected, corresponding complications can arise. If left untreated, late-stage complications can lead to death. However, if treated early, there is a possibility of cure over time.