Does stage II rectal cancer require chemotherapy?

Written by Liu Liang
Oncology
Updated on September 12, 2024
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Whether a stage II colorectal cancer patient needs adjuvant chemotherapy after surgery depends on the specific circumstances. For example, stage IIA patients are classified as T3, N0, M0. The necessity of adjuvant chemotherapy for these patients should be determined based on the pathological report. If the report indicates the presence of vascular invasion, neural invasion, poor differentiation, or if microsatellite stability testing shows poor prognostic factors, then such patients should undergo postoperative adjuvant chemotherapy. If none of these conditions are present in a stage IIA patient, then postoperative adjuvant chemotherapy may not be necessary. Generally, stage IIB patients, whose tumors have penetrated the full thickness of the intestinal wall, are recommended to undergo postoperative adjuvant chemotherapy. Therefore, the specific conditions of the patient need to be considered.

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Is rectal cancer without metastasis curable?

Can rectal cancer without metastases be treated successfully? If rectal cancer has not metastasized, its prognosis and outcome are relatively much better compared to cases where there are metastases and recurrences. If surgery is performed for rectal cancer and there is no recurrence or metastasis afterwards, then the five-year survival rate is naturally higher. However, if rectal cancer is initially treated surgically and cleaned thoroughly but then quickly recurs, with liver metastases, lung metastases, etc., then the five-year survival rate would be much lower. Therefore, if rectal cancer has not metastasized, the treatment and prognosis are much better. Thus, if there is no liver or lung metastasis in rectal cancer, the treatment is relatively easier.

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What tests are used to check for rectal cancer?

When clinical symptoms such as diarrhea or constipation, changes in bowel habits, bloody stools, and abdominal pain occur, we should be vigilant about the possibility of rectal cancer. The examination for rectal cancer can start with a digital rectal exam, especially for low-lying rectal cancer, which is closer to the anus; these tumors can be detected through this method. Then, a colonoscopy should be performed to take a biopsy to confirm the diagnosis, which is the gold standard for confirmation. Additionally, blood tests for tumor markers can be conducted. Generally, carcinoembryonic antigen (CEA) and CA199 levels may be elevated, but this is not absolute as their specificity and sensitivity are not very high. An enhanced CT scan of the abdomen can also be done. In such scans, we can see thickening of the intestinal wall where the tumor is located, and the enhancement can show the intensified thickening of the intestinal wall. Combining all these methods can confirm the diagnosis of rectal cancer.

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What are the late-stage symptoms of rectal cancer?

The late-stage symptoms of rectal cancer patients in clinical practice mainly include the following types. The first type is abdominal symptoms caused locally by rectal cancer. For example: bloody stools, pass stools with mucous and pus, anal pain, bloating, abdominal pain, and other manifestations. The second category of symptoms is those from metastases in various locations. For example, bone metastases cause bone pain and limb movement disorders. Lung metastases cause chest tightness, shortness of breath after activity, chest pain, breathing difficulties, coughing and coughing up blood, etc. Brain metastases cause headaches, dizziness, and seizures. The third category of symptoms is mainly systemic symptoms caused by rectal cancer lesions, such as: weight loss, fatigue, and high fever.

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Does stage II rectal cancer require chemotherapy?

Whether a stage II colorectal cancer patient needs adjuvant chemotherapy after surgery depends on the specific circumstances. For example, stage IIA patients are classified as T3, N0, M0. The necessity of adjuvant chemotherapy for these patients should be determined based on the pathological report. If the report indicates the presence of vascular invasion, neural invasion, poor differentiation, or if microsatellite stability testing shows poor prognostic factors, then such patients should undergo postoperative adjuvant chemotherapy. If none of these conditions are present in a stage IIA patient, then postoperative adjuvant chemotherapy may not be necessary. Generally, stage IIB patients, whose tumors have penetrated the full thickness of the intestinal wall, are recommended to undergo postoperative adjuvant chemotherapy. Therefore, the specific conditions of the patient need to be considered.

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Is a faint pain below the center of the lower abdomen indicative of rectal cancer?

There is a vague pain just below the middle of the lower abdomen, and although there is a possibility of rectal cancer, it is not necessarily certain to be rectal cancer. There are many reasons for pain in this area; common causes to consider include intestinal infection or intestinal spasms and obstruction. Tumors can also cause pain in this area. In women, pain just below the middle of the lower abdomen also needs to exclude the possibility of pelvic inflammatory disease or gynecological inflammation, etc. It is necessary to complete examinations such as a color ultrasound and an upright abdominal plain film for confirmation. If the pain occurs repeatedly, further examinations including a complete blood count, inflammatory markers, and other relevant inflammation tests should also be completed for a clear diagnosis.