What are the symptoms of neonatal jaundice?

Written by Shi Ji Peng
Pediatrics
Updated on March 19, 2025
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Neonatal jaundice generally appears on the 2nd to 3rd day after birth and can manifest with yellowing of the skin, conjunctiva, and oral mucosa. The degree of jaundice varies, usually more noticeable on the face and chest, but not present on the palms of the hands or soles of the feet. It is most apparent on the 4th to 6th day after birth. The duration of jaundice also varies; in full-term infants, jaundice typically subsides within 10-14 days after birth, whereas in premature infants, it can last until the third or even the fourth week. During this period, infants with physiological jaundice are generally in good condition without any other discomfort and do not require treatment. However, pathological jaundice must be investigated for its cause. Pathological jaundice is primarily characterized by an early onset, severe degree, prolonged duration, or recurrence of jaundice. In such cases, it is classified as pathological jaundice, and it is crucial to actively search for the cause and treat accordingly based on the identified cause.

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Causes of neonatal jaundice

Neonatal jaundice is relatively common and its causes are usually related to the characteristics of neonatal bilirubin metabolism, which are mainly manifested in the following aspects: First, excessive production of bilirubin; second, poor ability of plasma albumin to bind bilirubin; third, poor ability of liver cells to process bilirubin; fourth, the enterohepatic circulation is more prevalent than in adults, thus making physiological jaundice more likely to occur. Furthermore, some children are affected by breastfeeding, with a portion of breastfed babies experiencing breast milk jaundice. Other factors include pathological reasons, such as viral infections common in hepatotropic viruses like cytomegalovirus, TORCH, etc.; jaundice can also occur following exposure to cold, which can lead to decreased resistance and bacterial infections; additionally, some children have jaundice due to genetic metabolic reasons.

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neonatal jaundice subsidence time

Neonatal jaundice is a common phenomenon and a unique condition in newborns. If it is normal physiological jaundice, it generally subsides within two weeks for full-term infants born after 37 weeks. This means that after two weeks, the jaundice is essentially gone; the skin and eyes are no longer yellow, and bilirubin levels are typically below 6-7, which is considered normal. For premature infants, the jaundice generally clears within four weeks. If the jaundice persists longer, there might be some pathological factors involved, and it is advisable to visit a hospital for a thorough evaluation by a doctor to determine if any special treatment is needed.

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What does a newborn jaundice blood test check for?

Neonatal jaundice is one of the common symptoms during the neonatal period. It may indicate both normal developmental processes and certain diseases. If it is normal physiological jaundice, there is no need for blood tests. However, if pathological jaundice is suspected, blood tests are generally required. The most common test is a liver function test to determine the level of bilirubin in the blood. Additional tests might be conducted, especially if there is an incompatibility in the blood type between the mother and child. In such cases, tests for the baby's blood type and hemolysis are necessary, along with tests for common infection markers. If the mother had other abnormalities before pregnancy, further blood tests might be warranted based on potential conditions that the baby might exhibit.

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Neonatal jaundice peak period is a few days.

Neonatal jaundice is one of the common symptoms during the neonatal period; it could be a normal physiological phenomenon, or it might be an external manifestation of certain diseases. Typically, physiological jaundice appears two to three days after birth, reaches its peak within four to five days in full-term infants, and may appear sooner and be more severe in preterm infants due to their less mature liver function. The peak period lasts longer for preterm babies; generally, in full-term infants, jaundice usually starts declining about a week later, subsiding around ten days, generally not lasting more than two weeks.

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Can neonatal jaundice be effectively treated?

Neonatal jaundice refers to the development of jaundice involving the whole body's skin and mucous membranes in newborns. For physiological jaundice in newborns, it can heal naturally. For pathological jaundice in newborns, with active treatment, including phototherapy, etiological treatment, and when necessary, administration of medications such as albumin and globulin, the more severe cases may require blood exchange treatment. Through the aforementioned treatments, neonatal jaundice can be effectively managed, so parents need not worry. If you notice jaundice in your child, actively take them to the hospital to cooperate with the doctor's treatment. In most cases, a satisfactory treatment outcome can be achieved. Parents can be reassured in this regard. (Please follow the guidance of a specialist for specific medications and do not medicate on your own.)