There are several types of cervical cancer vaccines.

Written by Li Shun Hua

Obstetrics and Gynecology

Updated on April 05, 2025

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There are three types of cervical cancer vaccines: bivalent, quadrivalent, and nonavalent, and the recommended vaccination ages vary for each. The bivalent cervical cancer vaccine is suitable for females aged 9 to 45; the quadrivalent vaccine is suitable for females aged 20 to 45; the nonavalent vaccine is suitable for females aged 16 to 26. Vaccinations can be scheduled at hospitals within these age ranges. The younger the age at vaccination, the higher the antibody production after receiving the cervical cancer vaccine, meaning the effectiveness is better.

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Causes of cervical cancer

The causes of cervical cancer are particularly associated with human papillomavirus (HPV) infection. The primary causes that can lead to precancerous lesions and cervical cancer itself, in a minority of cases, do not detect HPV DNA, especially in older patients. Epidemiological studies show that early childbirth and multiple childbirths are highly related to the incidence of cervical cancer; as the number of childbirths increases, the risk of cervical cancer also increases. Smoking can suppress the body's immune function and may promote cancer development. Men who have had penile cancer, prostate cancer, or previous cervical cancer are at high risk; therefore, women who have contact with high-risk men are also more susceptible to cervical cancer.

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Does cervical cancer hurt?

Early cervical cancer generally has no obvious symptoms, often manifesting as vaginal discharge with blood streaks or bleeding after intercourse. However, if not treated timely, the condition can progress to an advanced stage where the growth of the cancer may compress surrounding tissues, possibly causing swelling and pain in the lower body and back pain. If the cancer cells spread throughout the body and affect nerves, stubborn pain can occur, and when bone metastasis occurs, localized bone pain can also be experienced.

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Obstetrics and Gynecology

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latent period of cervical cancer

The latency period for cervical cancer is generally five to ten years. The occurrence of cervical cancer is mainly due to exposure to the human papillomavirus (HPV) in the body. Typically, this virus persists and replicates within the body, leading to cervical cancer and precancerous lesions. From the initial virus infection to the development of cervical cancer, it usually takes a vast majority about five to ten years. Furthermore, different types of virus infections lead to varying probabilities of cervical cancer. In general, if the infection involves types 16 and 18 of the virus, the likelihood of developing cervical cancer is particularly high. Therefore, if one is infected with HPV types 16 and 18, it is crucial to undergo a cervical TCT test. If necessary, a cervical biopsy is generally performed under colposcopy, followed by treatment based on the examination results. Thus, to prevent cervical cancer, it is essential for women to undergo regular annual cervical cancer screening.

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Causes of Cervical Cancer

The causes of cervical cancer include: The first point is infection by the human papillomavirus (HPV), particularly persistent infection with high-risk types, which is the basic cause of precancerous lesions and cervical cancer. The second point is that DNA from HPV is not detected in the tumor tissues of a minority of cases, especially among some older patients. Epidemiology shows that early childbirth and multiparity are closely related to the occurrence of cervical cancer. With an increasing number of childbirths, the risk of cervical cancer also increases. This correlation might be due to the trauma to the cervix during childbirth and changes to the endocrine and nutritional states during pregnancy.

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Symptoms of cervical cancer

The most typical early symptom of cervical cancer is usually contact bleeding during intercourse. Clinically, once contact bleeding occurs, it is essential to go to the hospital for cervical cancer screening as soon as possible, generally involving a cervical TCT and HPV test. These two tests can initially screen for the presence of cervical cancer and precancerous lesions. If it has progressed to the stage of cervical cancer, there may be a large amount of vaginal discharge with a foul smell, and severe cases can have symptoms like bleeding and abdominal pain. Therefore, patients with cervical cancer must undergo relevant cervical examinations at the hospital. If it is indeed cervical cancer, treatment options should be selected based on the stage of the disease to treat the symptoms accordingly. Hence, if there is any irregular vaginal bleeding, it is critical to go to the hospital for the relevant cancer screening.