Causes of cervical cancer

Written by Gong Chun
Oncology
Updated on September 03, 2024
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The causes of cervical cancer are particularly associated with human papillomavirus (HPV) infection. The primary causes that can lead to precancerous lesions and cervical cancer itself, in a minority of cases, do not detect HPV DNA, especially in older patients. Epidemiological studies show that early childbirth and multiple childbirths are highly related to the incidence of cervical cancer; as the number of childbirths increases, the risk of cervical cancer also increases. Smoking can suppress the body's immune function and may promote cancer development. Men who have had penile cancer, prostate cancer, or previous cervical cancer are at high risk; therefore, women who have contact with high-risk men are also more susceptible to cervical cancer.

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Written by Gong Chun
Oncology
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Late-stage symptoms of cervical cancer

What are some symptoms of late-stage cervical cancer? First, there may be vaginal bleeding, characterized by irregular vaginal bleeding. The amount of bleeding varies depending on the size of the lesion and the invasion of interstitial blood vessels. In the late stages, as major blood vessels may be eroded, significant bleeding can occur. The second symptom is vaginal discharge, which is often increased and may be white or blood-stained. Third, late-stage symptoms may include secondary symptoms such as involvement of adjacent tissues and organs and affected nerves, leading to frequent urination, urgency, constipation, swelling and pain in the lower limbs. Cancer pressing on the ureters can cause obstruction of the ureters, hydronephrosis, and uremia. Late stages may also present with symptoms of systemic failure such as anemia and cachexia.

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Written by Xu Xiao Ming
Obstetrics and Gynecology
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Can cervical cancer be cured?

Cervical cancer can be treated with options including surgery, radiotherapy, and chemotherapy. For Stage 1A1 cervical cancer, a conization surgery can be chosen; for stages from 1A2 up to before 2B, a radical hysterectomy with bilateral adnexectomy and pelvic lymphadenectomy can be selected; if it is Stage 2B, where the cancer has spread to the parametrium, it is recommended to first undergo chemotherapy as preoperative neoadjuvant therapy to reduce the tumor size before proceeding with surgery; if the cancer has progressed to Stage 3A1 and beyond, radiotherapy or chemotherapy is recommended. In summary, surgical treatment can be chosen for cervical cancer before Stage 2B; if it is Stage 2B or later, involving the parametrium or the lower third of the vagina, surgery is generally not an option, and the treatment usually involves radiotherapy or chemotherapy.

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Written by Yan Qiao
Obstetrics and Gynecology
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Does cervical cancer hurt?

For patients with cervical cancer, the most common clinical manifestations are bleeding during sexual intercourse and irregular vaginal bleeding. Patients who have undergone menopause may also experience irregular vaginal bleeding post-menopause, and some patients may not show any clinical signs at a very early stage. As the cancer progresses, and when it invades nearby organs and metastasizes, it may cause lower abdominal distension and pain, and even more severe pain if the metastatic organs compress nerves or directly invade areas containing nerves.

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Written by Li Shun Hua
Obstetrics and Gynecology
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There are several types of cervical cancer vaccines.

There are three types of cervical cancer vaccines: bivalent, quadrivalent, and nonavalent, and the recommended vaccination ages vary for each. The bivalent cervical cancer vaccine is suitable for females aged 9 to 45; the quadrivalent vaccine is suitable for females aged 20 to 45; the nonavalent vaccine is suitable for females aged 16 to 26. Vaccinations can be scheduled at hospitals within these age ranges. The younger the age at vaccination, the higher the antibody production after receiving the cervical cancer vaccine, meaning the effectiveness is better.

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Written by Gong Chun
Oncology
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Cervical Cancer Staging Criteria

For the staging of cervical cancer, the staging criteria of the International Federation of Gynecology and Obstetrics (FIGO) are now adopted. Staging should be done before treatment, and since the FIGO staging of the cervix mainly relies on the examination of the pelvis, it is emphasized that the pelvic examination must be performed by two senior gynecologic oncologists. The staging primarily involves assessing the size of the cervical lesion, particularly the measurement of endophytic tumors, parametrial tissue infiltration, and the status of pelvic lymph nodes. However, these stages mainly rely on radiological examinations, primarily magnetic resonance imaging (MRI), to provide objective data for staging.