latent period of cervical cancer

Written by Zhang Xiu Rong
Obstetrics and Gynecology
Updated on November 05, 2024
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The latency period for cervical cancer is generally five to ten years. The occurrence of cervical cancer is mainly due to exposure to the human papillomavirus (HPV) in the body. Typically, this virus persists and replicates within the body, leading to cervical cancer and precancerous lesions. From the initial virus infection to the development of cervical cancer, it usually takes a vast majority about five to ten years. Furthermore, different types of virus infections lead to varying probabilities of cervical cancer. In general, if the infection involves types 16 and 18 of the virus, the likelihood of developing cervical cancer is particularly high. Therefore, if one is infected with HPV types 16 and 18, it is crucial to undergo a cervical TCT test. If necessary, a cervical biopsy is generally performed under colposcopy, followed by treatment based on the examination results. Thus, to prevent cervical cancer, it is essential for women to undergo regular annual cervical cancer screening.

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Late-stage symptoms of cervical cancer

What are some symptoms of late-stage cervical cancer? First, there may be vaginal bleeding, characterized by irregular vaginal bleeding. The amount of bleeding varies depending on the size of the lesion and the invasion of interstitial blood vessels. In the late stages, as major blood vessels may be eroded, significant bleeding can occur. The second symptom is vaginal discharge, which is often increased and may be white or blood-stained. Third, late-stage symptoms may include secondary symptoms such as involvement of adjacent tissues and organs and affected nerves, leading to frequent urination, urgency, constipation, swelling and pain in the lower limbs. Cancer pressing on the ureters can cause obstruction of the ureters, hydronephrosis, and uremia. Late stages may also present with symptoms of systemic failure such as anemia and cachexia.

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Can a cervical biopsy detect cervical cancer?

Cervical biopsy can detect cervical cancer as long as the altered tissue is collected. However, some people have a type 3 transformation zone in the cervix, making it difficult to obtain the altered tissue, and in these cases, cervical scraping is needed. Therefore, it is best to perform the biopsy under colposcopic examination and conduct a cervical canal scraping at the same time. If there is cervical cancer, it can be detected, and generally, it will not be missed.

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Is cervical hypertrophy cervical cancer?

In clinical practice, most cases of cervical hypertrophy are not cervical cancer, but normal women do not have cervical hypertrophy. It is recommended that patients who suspect cervical hypertrophy should immediately visit the obstetrics and gynecology clinic of their local hospital, undergo a gynecological color ultrasound, and a gynecological examination to determine the cause of the cervical hypertrophy. The gynecological examination mainly relies on the doctor's visual assessment of the size of the cervix, and observation of any obvious lesions on the surface of the cervix. Additionally, gynecological ultrasound can be used to identify potential lesions in parts of the cervix that are not visible to the naked eye.

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How to check for cervical cancer if unmarried

For unmarried women, if there is no sexual activity, they generally do not need to undergo cervical cancer screening. This is because the cause of cervical cancer has been clearly established as being caused by HPV virus infection, mainly transmitted through sexual contact. Therefore, unmarried women without sexual activity might not consider cervical cancer screening necessary. However, it is still recommended for unmarried women who are sexually active to undergo cervical cancer screening, especially if they started sexual activity at a young age and have multiple sexual partners. The screening generally includes HPV testing, cytology (TCT), and colposcopy.

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Precursors of cervical cancer

The occurrence and development of the cervix is a process from quantitative to qualitative change, evolving gradually to a sudden shift over a long period. The precursor might be the heterotypic zone of the cervix, which is a common site for abnormalities. During the formation of this heterotypic zone, cervical epithelial metaplasia is relatively active, and, compounded by infection with the human papillomavirus and further stimulated by external carcinogens, immature or proliferative squamous epithelial cells may exhibit gradual changes or atypical hyperplasia, potentially leading to sarcomatoid changes in the cervical epithelium. This might be a precursor sign.