Causes of Cervical Cancer

Written by Gong Chun
Oncology
Updated on September 29, 2024
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The causes of cervical cancer include: The first point is infection by the human papillomavirus (HPV), particularly persistent infection with high-risk types, which is the basic cause of precancerous lesions and cervical cancer. The second point is that DNA from HPV is not detected in the tumor tissues of a minority of cases, especially among some older patients. Epidemiology shows that early childbirth and multiparity are closely related to the occurrence of cervical cancer. With an increasing number of childbirths, the risk of cervical cancer also increases. This correlation might be due to the trauma to the cervix during childbirth and changes to the endocrine and nutritional states during pregnancy.

Other Voices

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Written by Gong Chun
Oncology
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Cervical Cancer Staging Criteria

For the staging of cervical cancer, the staging criteria of the International Federation of Gynecology and Obstetrics (FIGO) are now adopted. Staging should be done before treatment, and since the FIGO staging of the cervix mainly relies on the examination of the pelvis, it is emphasized that the pelvic examination must be performed by two senior gynecologic oncologists. The staging primarily involves assessing the size of the cervical lesion, particularly the measurement of endophytic tumors, parametrial tissue infiltration, and the status of pelvic lymph nodes. However, these stages mainly rely on radiological examinations, primarily magnetic resonance imaging (MRI), to provide objective data for staging.

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Written by Xu Xiao Ming
Obstetrics and Gynecology
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Is cervical hypertrophy cervical cancer?

Cervical hypertrophy is not cervical cancer. Cervical hypertrophy is merely a change in the shape and size of the cervix, which becomes larger than normal, and its shape might be somewhat larger than a normal cervix. It is just a morphological change. Cervical cancer, on the other hand, is caused by an HPV virus infection. It is a type of tumor and is different from mere enlargement; one is cancer, and the other is just an increase in size. Therefore, it is recommended that patients who experience irregular vaginal bleeding after intercourse, as well as those who have irregular bleeding normally, should undergo screening for cervical cancer, including tests for HPV and TCT.

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Written by Liu Jian Wei
Obstetrics and Gynecology
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Cervical cancer is divided into several stages.

Cervical cancer is categorized into four stages based on the extent of the cancer lesion, with different stages receiving different treatments clinically. Stage I cervical cancer is the earliest stage, while stage IV cervical cancer is the latest stage, often invading organs beyond the reproductive system. Clinically, early-stage cervical cancer is primarily treated with surgical resection, followed by postoperative radiotherapy and chemotherapy to reduce the likelihood of cancer recurrence. In contrast, late-stage cervical cancer is treated primarily with radiotherapy and chemotherapy.

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Written by Li Shun Hua
Obstetrics and Gynecology
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Is cervical polyp cervical cancer?

Cervical polyps are not cervical cancer. Most cervical polyps are caused by chronic inflammation of the cervix, whereas cervical cancer is caused by human papillomavirus (HPV) infection. After removing a cervical polyp and conducting a pathological examination, if it is benign, it is considered cured. However, cervical cancer is a malignant tumor that requires surgery. If high-risk factors are present after surgery, radiotherapy and chemotherapy are necessary. Therefore, these two diseases are different and vary in severity.

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Written by Zhang Xiu Rong
Obstetrics and Gynecology
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latent period of cervical cancer

The latency period for cervical cancer is generally five to ten years. The occurrence of cervical cancer is mainly due to exposure to the human papillomavirus (HPV) in the body. Typically, this virus persists and replicates within the body, leading to cervical cancer and precancerous lesions. From the initial virus infection to the development of cervical cancer, it usually takes a vast majority about five to ten years. Furthermore, different types of virus infections lead to varying probabilities of cervical cancer. In general, if the infection involves types 16 and 18 of the virus, the likelihood of developing cervical cancer is particularly high. Therefore, if one is infected with HPV types 16 and 18, it is crucial to undergo a cervical TCT test. If necessary, a cervical biopsy is generally performed under colposcopy, followed by treatment based on the examination results. Thus, to prevent cervical cancer, it is essential for women to undergo regular annual cervical cancer screening.