Common symptoms of primary liver cancer

Written by Liu Liang
Oncology
Updated on May 09, 2025
00:00
00:00

The initial symptoms of primary liver cancer are mostly pain in the liver area, which commonly presents as abdominal pain. Some patients may also experience bloating, fatigue, and weight loss as systemic symptoms. In advanced-stage liver cancer patients, there can be an enlargement of the liver, meaning a palpable enlarged mass can be felt in the abdomen. Other symptoms include jaundice and ascites, which can cause abdominal bloating. Upon physical examination, an obvious increase in abdominal girth and abdominal distension can be noted. Moreover, patients with advanced liver cancer may also suffer from complications such as upper gastrointestinal bleeding, rupture and bleeding of the liver cancer nodules, liver failure, and even hepatic encephalopathy, among others.

Other Voices

doctor image
home-news-image
Written by Li Hu Chen
Imaging Center
54sec home-news-image

Liver cancer B-ultrasound manifestations

Generally speaking, for diseases of the hepatobiliary system, most of us conduct examinations using ultrasound because it is very convenient, safe, involves no radiation, and the results are relatively quick. Generally, liver cancer can appear as hypoechoic, hyperechoic, or mixed echogenicity on ultrasound. Most such liver cancer nodules may have a complete capsule, but some may not have a complete capsule. Overall, this type of liver cancer tends to grow expansively and invasively, compressing the surrounding normal liver tissue, and possibly showing some halo signs around it. The vast majority of liver cancers do not occur independently; they usually develop gradually from cirrhosis. Therefore, there is often an enlargement of the portal vein, and in some cases of liver cancer with metastasis, thrombosis in the portal vein can be seen.

doctor image
home-news-image
Written by Liu Liang
Oncology
43sec home-news-image

Primary liver cancer causes

The causes and specific mechanisms of primary liver cancer are not yet very clear; its development is a complex process involving multiple factors and steps, influenced by various aspects such as environment and diet. Primary liver cancer is associated with chronic hepatitis B and C virus infections, aflatoxin, contaminated drinking water, and alcoholic cirrhosis, among other factors. Particularly, hepatocellular carcinoma has a significant association with hepatitis B, and most patients may also have a history of chronic hepatitis B.

doctor image
home-news-image
Written by Cui Fang Bo
Oncology
55sec home-news-image

Why does advanced liver cancer cause itching on the body?

Liver cancer itself does not cause itchy skin, but itchy skin can appear in advanced liver cancer patients due to some complications. Firstly, when liver cancer encroaches on the hepatic portal area, it can invade or compress the biliary system, causing obstruction of the biliary system and increased bilirubin in the blood, which leads to generalized itching. When liver cancer patients also have fungal or parasitic infections of the skin, itching can also occur. Additionally, when liver cancer patients undergo chemotherapy, targeted molecular therapy, or other systemic anti-tumor treatments, they may experience generalized itching due to allergies to medications. In some cases where the allergic reactions are severe, symptoms such as a drop in blood pressure and other manifestations of anaphylactic shock can occur, necessitating prompt treatment.

doctor image
home-news-image
Written by Cui Fang Bo
Oncology
1min 3sec home-news-image

Will early-stage liver cancer cause a low-grade fever?

Patients with early-stage liver cancer may experience low-grade fevers, primarily due to the following two reasons: First, tumor fever. In the early stages of liver cancer, some tumor cells can release tumor mediators into the bloodstream, affecting the function of the temperature regulation center and causing the patient to develop a fever. This type of tumor fever is usually not very high, remaining below 38.5°C, without concurrent symptoms or signs of infection. A complete blood count typically indicates that the total number of white blood cells and the proportion of neutrophils are not elevated. The second scenario involves patients in the early stages of liver cancer experiencing fever due to concurrent infections. These patients often present with symptoms and signs related to infection, such as coughing up phlegm, abdominal pain and diarrhea, and urinary frequency, urgency, or pain. The proportion of white blood cells and neutrophils is significantly increased in these cases.

doctor image
home-news-image
Written by Sun Wei
Surgical Oncology
48sec home-news-image

Early symptoms of primary liver cancer

Primary liver cancer often shows no obvious symptoms in its early stages. It may present symptoms similar to indigestion, hepatitis, etc. For example, there might be slight discomfort or pain in the upper right abdomen, aversion to oil, or loss of appetite. Generally, regular health check-ups are needed, including imaging studies of the liver such as ultrasound, CT, or MRI. Liver function tests and tumor markers such as alpha-fetoprotein (AFP) should also be performed. In most cases of primary liver cancer, AFP levels will be elevated. Combined with imaging studies, a preliminary diagnosis can be made. A definitive diagnosis requires liver biopsy or confirmation through pathology after surgery.