Does early-stage liver cancer cause the complexion to become dark?

Written by Yan Chun
Oncology
Updated on March 09, 2025
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Patients with early-stage liver cancer do not experience darkening of the facial complexion. This is because early-stage liver cancer primarily refers to carcinoma in situ of the liver and some small liver cancers. Since the tumors are small and the affected area is limited, they generally cause few symptoms clinically. Some patients may experience mild fatigue and a decrease in appetite, but these do not lead to changes in the complexion. Only when the liver cancer progresses to the middle or late stages, causing damage to liver cell functions or when the pathology metastasizes, leading to damage to multiple organ functions, can there be some changes in facial complexion. For example, patients may exhibit pale complexions due to moderate to severe anemia. Some patients may have yellowing of the skin due to obstructive jaundice or hepatocellular jaundice. Additionally, some patients may show darkening of the facial complexion due to abnormal hormone secretion.

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Written by Yan Chun
Oncology
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Does liver cancer cause nosebleeds in its early stages?

Patients with early-stage liver cancer generally do not exhibit clinical symptoms of nosebleeds. Nosebleeds are a clinical manifestation of late-stage liver cancer. Early-stage liver cancer patients usually have atypical symptoms, which may include tenderness in the liver area, decreased appetite, abdominal bloating, and symptoms of indigestion. As the disease progresses, the liver cancer invades surrounding tissues and metastasizes to distant sites, leading to liver function impairment and coagulation disorders, which can result in nosebleeds. Some patients may also develop splenic hyperfunction due to liver damage, leading to a decrease in platelets, which can also cause nosebleeds. Additionally, some patients in the late stages may develop disseminated intravascular coagulation, leading to spontaneous internal and mucosal bleeding, clinically manifesting as nosebleeds.

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Written by Yan Chun
Oncology
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Early Symptoms and Warning Signs of Liver Cancer

The early symptoms of liver cancer primarily manifest as localized gastrointestinal symptoms. Patients develop an aversion to greasy foods and experience a decrease in appetite. Some may feel bloating and pain in the abdomen, nausea, and distention after eating, and even pain and bloating as early symptoms. Patients become reluctant to be active, and some liver cancer patients may not exhibit many symptoms in the early stages. The precursors of liver cancer mainly present as unexplained fatigue or generalized weakness. If individuals with a family history of liver cancer experience unexplained anorexia, fatigue, and lethargy, the possibility of liver cancer should be considered.

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Written by Cui Fang Bo
Oncology
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Will early-stage liver cancer cause a low-grade fever?

Patients with early-stage liver cancer may experience low-grade fevers, primarily due to the following two reasons: First, tumor fever. In the early stages of liver cancer, some tumor cells can release tumor mediators into the bloodstream, affecting the function of the temperature regulation center and causing the patient to develop a fever. This type of tumor fever is usually not very high, remaining below 38.5°C, without concurrent symptoms or signs of infection. A complete blood count typically indicates that the total number of white blood cells and the proportion of neutrophils are not elevated. The second scenario involves patients in the early stages of liver cancer experiencing fever due to concurrent infections. These patients often present with symptoms and signs related to infection, such as coughing up phlegm, abdominal pain and diarrhea, and urinary frequency, urgency, or pain. The proportion of white blood cells and neutrophils is significantly increased in these cases.

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Written by Luo Han Ying
Endocrinology
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Can pain around the belly button be liver cancer?

The tissues around the navel are primarily intestinal tissues. The outer ring is the large intestine, and close to the navel is mainly the small intestine. If there is pain around the navel that feels like pulling or bloating, and it relieves after defecation, then it is generally enteritis. The liver, on the other hand, is located in the upper right part of the abdomen, below the rib margin. If pain occurs in this area, the possibility of liver cancer is high, and the two types of pain are completely different. Pain around the navel is mainly pulling pain, and it is not very severe; whereas liver pain is primarily bloating pain, which is very severe, and general medications cannot alleviate it. Therefore, pain around the navel is unlikely to be liver cancer.

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How to reduce fever in late-stage liver cancer

For late-stage liver cancer patients experiencing fever, antipyretic treatment should be based on different circumstances. If the fever is due to an infection, it often exceeds 39℃ and is accompanied by symptoms and signs related to the infection, such as cough and yellow sputum, abdominal pain, diarrhea, frequent urination, urgency, and painful urination. In such cases, antibiotics should be used for anti-infective treatment, along with antipyretic analgesics for fever reduction. If the fever is due to tumor fever or interventions like liver procedures, there are no infection-related factors, usually the temperature does not exceed 38.5℃, and there are no symptoms or signs related to infection. The treatment primarily involves the use of antipyretic analgesics for fever reduction.