What are the early symptoms of liver cancer?

Written by Liu Liang
Oncology
Updated on September 24, 2024
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The early symptoms of liver cancer lack specificity, so in clinical practice, early-stage liver cancer is generally detected only during routine screenings or physical examinations. By the time patients present with noticeable symptoms and seek medical attention, the cancer is often in the intermediate or advanced stages, making surgical removal unlikely for most patients. The early symptoms might include non-specific signs such as fatigue. It is usually only in the intermediate or advanced stages that patients experience obvious symptoms like pain in the liver area, palpable abdominal masses, abdominal distension, weight loss, and jaundice. By the time these symptoms appear, it is typically quite late, corresponding to the intermediate or advanced stages of the disease. Early stages typically do not show specific symptoms, though some patients might experience mild abdominal pain, bloating, or fatigue, which are not very specific signs.

Other Voices

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Written by Cui Fang Bo
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What should I do if I have liver cancer and a fever of 38 degrees Celsius?

Liver cancer patients experiencing a fever of 38°C can be seen in the following scenarios: The first type is tumor-related fever. In liver cancer patients, especially those in the advanced stages or with large tumors, a fever of around 38°C can occur in the absence of infection symptoms. This tumor fever is related to various mediators released into the blood by the tumor. The second type is infectious fever. Cancer patients undergoing anti-tumor treatment may experience immunosuppression and concurrent infections. This type of fever often exceeds 38.5°C but can also occur around 38°C in the early stages, often accompanied by symptoms of infection such as coughing, sputum production, abdominal pain, and diarrhea. The third type is treatment-related fever. Patients with liver cancer may experience a fever of around 38°C on the day of and several days following interventional treatments.

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Written by Yan Chun
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Does early-stage liver cancer metastasize?

Patients with early-stage liver cancer generally do not experience metastasis. This is because for patients with early-stage liver cancer, the lesions are localized and have not spread, thus being classified as early-stage. Moreover, the general treatment for patients with early-stage liver cancer involves curative surgery. Since the lesions are localized, in most cases, there will be no recurrence or metastasis after the surgery. Therefore, for early-stage patients, there is no need to administer adjuvant radiotherapy or adjuvant chemotherapy and other anti-tumor treatments after the surgery. However, once the liver cancer lesions invade surrounding tissues and metastasize to distant sites, it indicates that the lesions have spread, and the clinical stage has progressed to mid or late stages, losing the opportunity for curative surgery. Most patients undergo comprehensive treatments such as radiotherapy, chemotherapy, and targeted therapy which generally results in a reduction in survival time.

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Can early-stage liver cancer be cured by resection?

Liver cancer is one of the common malignant tumors of the digestive system. For patients with early-stage liver cancer, clinical cure is possible after curative surgery. This clinical cure refers to instances where liver cancer patients, after undergoing curative surgery, do not show signs of recurrence or metastasis over a period exceeding five years. This means there is no invasion of surrounding tissues and no metastasis to distant organs – effectively, the patients have achieved clinical cure. Patients' survival time exceeds five years, or even longer. Therefore, for patients with early-stage liver cancer, because their lesions are relatively limited, achieving clinical cure is possible following curative surgery. However, as the disease progresses to the mid and late stages, even with aggressive surgery and postoperative adjuvant radiotherapy or chemotherapy, most patients cannot achieve clinical cure.

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The difference between primary liver cancer and secondary liver cancer

Primary liver cancer, also commonly referred to as liver cancer, originates in the liver itself and is not transferred from other parts of the body. Secondary liver cancer occurs when the primary tumor originates in another location and then metastasizes to the liver, causing hepatic space-occupying lesions; this is referred to as secondary liver cancer. The main difference between the two types is their origin. Additionally, primary liver cancer is often solitary but may develop intrahepatic or distant metastases as the disease progresses. In cases of secondary liver cancer, multiple intrahepatic metastatic lesions may be discovered at the onset. Moreover, primary liver cancer may often display an elevated alpha-fetoprotein tumor marker, whereas this marker might be normal in secondary liver cancer.

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Symptoms of late-stage liver cancer deterioration

If liver cancer reaches an advanced stage, many symptoms will appear. For example, there will be pain in the liver area due to the tumor's growth pulling on the liver capsule, causing persistent swelling in the upper right part or stomach pain. If the tumor invades the pectoral muscles, it may cause referred pain in the right shoulder or back. Some patients may experience an enlarged liver due to the increased size of the tumor, which feels painful when pressed. Additionally, the increase and pressure from the tumor can obstruct bile excretion, leading to jaundice, and symptoms of cirrhosis may also appear. In general, the main symptoms of advanced liver cancer include fever, fatigue, loss of appetite, and weight loss. If the condition worsens, metastatic symptoms may occur; lung metastasis can cause the patient to cough and expel phlegm, and bone metastasis can cause localized pain and lumps.