Early symptoms of rickets

Written by Quan Xiang Mei
Pediatrics
Updated on February 13, 2025
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Rickets is a bone disease formed due to a deficiency of vitamin D, clinically referred to as rickets. The early clinical symptoms of rickets, which correspond to the early stages of vitamin D deficiency, primarily manifest as autonomic dysfunction, including night terrors, night sweats, and crying. In the early stages of rickets symptoms, parents often believe the cause to be calcium deficiency. Indeed, vitamin D deficiency can also impair calcium absorption, and these are linked reactions. Therefore, parents should pay attention to supplementing vitamin D, especially in areas with insufficient sunlight, ensuring that children receive less than two hours of sunlight exposure per day. During children's growth phases, it is essential to ensure adequate daily intake of vitamin D, with a basic amount of 400 IU being necessary.

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Written by Li Jiao Yan
Neonatology
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Can rickets be cured?

Rickets is a chronic nutritional disease caused by vitamin D deficiency that leads to disturbed calcium and phosphorus metabolism in the body, causing abnormal skeletal development. If a square skull is observed, it indicates that the child's disease has entered an active phase. Generally, in the early stages, there is an enlargement of the fontanelle or a delay in the closure of the fontanelle. By seven to eight months, a square skull can appear, primarily characterized by outward bulging centered on the frontal and parietal bones. At this time, it is generally necessary to administer a sufficient dose of vitamin D and encourage appropriate outdoor activities. Depending on the child's condition, it might be appropriate to supplement with calcium as well. Gradually, this should be curable; however, if there are other special causes for the abnormal vitamin D levels, such as severe liver or kidney disease or some new genetic diseases causing square skull, the treatment might be more challenging.

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Written by Li Jiao Yan
Neonatology
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Can rickets be treated?

Rickets is a disorder caused by a deficiency of vitamin D, leading to impaired calcium and phosphorus absorption, which then results in abnormal skeletal development. It is a chronic nutritional disease. Generally, the rickets commonly mentioned is due to nutritional vitamin D deficiency, which is treatable. Typically, encouraging children to engage in appropriate physical activities while supplementing with an adequate level of vitamin D can effectively control the disease, and it can even be cured. However, if there are special circumstances, such as significant liver abnormalities, renal function abnormalities, renal failure, or abnormalities in the thyroid or parathyroid glands, including parathyroid tumors, or congenital hereditary diseases, the treatment needs to be based on the cause in order to effectively control the disease and promote normal calcium and phosphorus metabolism in the body. Congenital hereditary diseases generally make treatment more challenging. Therefore, it is crucial for children with rickets to seek timely medical examination at a hospital. If it is a common case of nutritional vitamin D deficiency, parents should supplement vitamin D promptly according to the doctor's advice for treatment.

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Written by Li Jiao Yan
Neonatology
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Rickets is a disease that affects bone development in children due to vitamin D deficiency, calcium, or phosphate. It is treatable with proper nutrition and supplementation.

Rickets, also known as vitamin D deficiency rickets, is caused by a lack of vitamin D, leading to abnormal calcium and phosphorus metabolism in the body. The calcium salts cannot be properly deposited in the growing parts of the skeleton, causing incomplete mineralization of the bone tissue during growth. This results in a chronic systemic nutritional disease closely related to lifestyle, characterized by skeletal abnormalities. The most common is nutritional vitamin D deficiency, which is self-limiting. Typically, sufficient vitamin D supplementation and appropriate sun exposure can cure it. If caused by other severe diseases, vitamin D deficiency will significantly manifest liver and kidney function abnormalities. Additionally, some congenital genetic diseases make treatment more difficult when vitamin D levels are deficient.

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Written by Li Jiao Yan
Neonatology
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How is rickets diagnosed?

Rickets is a chronic nutritional disease characterized by skeletal changes, resulting from insufficient Vitamin D in children, which leads to disruptions in calcium and phosphorus metabolism. Diagnosis of rickets requires a measure of Vitamin D levels, clinical manifestations, certain biochemical markers in blood, and skeletal X-ray findings. Typically, Vitamin D levels are significantly lower than usual, with the level of 25-hydroxyvitamin D3 being the most reliable diagnostic standard. However, many facilities are unable to perform this test, so some instead rely on blood biochemistry and skeletal X-rays. Currently, blood biochemistry and skeletal X-ray examinations are considered the gold standard for diagnosis.

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Written by Yan Xin Liang
Pediatrics
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Does rickets have a hereditary component?

Rickets, also known as vitamin D deficiency rickets, is primarily a chronic nutritional disease characterized by skeletal lesions, caused by insufficient vitamin D in infants, children, or adolescents, which leads to disturbances in calcium and phosphorus metabolism. The main feature of this disease is the incomplete calcification of the growth plates and bone tissue in the growing long bones, due to the lack of vitamin D causing incomplete calcification of mature bones. This disease is most common in children under two years old. Its causes may be related to insufficient intake of vitamin D or insufficient sunlight exposure, as well as rapid growth. Additionally, other diseases may influence its development. Therefore, this disease is generally not closely related to genetics.