The difference between osteoarthritis and rheumatoid arthritis

Written by Cheng Bin
Orthopedics
Updated on March 22, 2025
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The so-called osteoarthritis often occurs as the patient ages, featuring localized bone hyperplasia and degenerative changes, leading to the destruction of cartilage. This results in congested and swollen synovium, manifesting as clear local symptoms of swelling and pain. Rheumatoid arthritis, on the other hand, mainly occurs due to a streptococcal infection, causing localized pain and swelling, thus forming rheumatoid arthritis. This is the difference between the two. There are also differences in treatment. Early osteoarthritis can be treated with oral non-steroidal anti-inflammatory and analgesic drugs, as well as medications that nourish the cartilage. For rheumatoid arthritis, symptomatic treatment is often necessary, and active anti-rheumatic treatment can be completely effective.

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Written by Wang Cheng Lin
Orthopedics
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The difference between arthritis and rheumatoid arthritis

The difference between arthritis and rheumatoid arthritis is significant. Arthritis is a degenerative lesion caused by factors such as obesity, overuse, and trauma, which lead to the degeneration of joint cartilage. Rheumatoid arthritis is caused by acute or chronic inflammation of the connective tissue, commonly referred to as rheumatic fever. Clinically, it is mainly characterized by migratory pain, redness and swelling in the joints and muscles. The cause of rheumatoid arthritis is not yet definite in clinical practice, and the treatments are different. Osteoarthritis mainly results from cartilage degeneration and can be managed with conservative treatment in its early stages, while surgery might be required in the later stages. The treatment for rheumatoid arthritis primarily relies on medications to alleviate symptoms, and this condition may eventually lead to significant deformities of the hands and feet. Therefore, the differences between these two diseases are considerable.

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Written by Yang Ya Meng
Rheumatology
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What causes rheumatoid arthritis?

The causes of rheumatoid arthritis are mainly classified into four categories, First, environmental factors, such as living in dark, damp conditions for a long period, may trigger the onset of rheumatoid arthritis. Second, genetic factors, the probability of developing rheumatoid arthritis significantly increases if a parent has the condition. Third, rheumatoid arthritis often relates to estrogen, thus it is more commonly seen in female patients clinically. Fourth, rheumatoid arthritis is also associated with certain infections, including some viral and bacterial infections.

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Written by Liu Li Ning
Rheumatology
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How is rheumatoid arthritis treated?

The treatment of rheumatoid arthritis is divided into general treatment and pharmacological treatment. General treatment mainly involves avoiding overexertion, having a light diet, and not staying up late. Pharmacological treatment is mainly divided into treatment during the acute flare-up phase and the remission phase. The acute phase focuses on anti-inflammatory and pain relief treatments, with non-steroidal anti-inflammatory drugs (NSAIDs) as the first choice, such as etoricoxib, meloxicam, or celecoxib. If the effect is not satisfactory, low-dose corticosteroid therapy may be combined. In the remission phase, slow-acting anti-rheumatic drugs are preferred, such as methotrexate, leflunomide, or sulfasalazine. If the slow-acting anti-rheumatic drugs are not effective, biologic agents such as tumor necrosis factor antagonists or JAK inhibitors may be combined.

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Written by Yang Ya Meng
Rheumatology
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Characteristics of rheumatoid arthritis in the hand

The key hand features of rheumatoid arthritis primarily manifest as symmetrical joint swelling and pain in both hands in the early stages. These swollen and painful joints include both wrist joints, bilateral metacarpophalangeal joints, and bilateral proximal interphalangeal joints. Rheumatoid arthritis rarely affects the distal interphalangeal joints of the hands. In the later stages of rheumatoid arthritis, due to the destruction of the hand joints by synovitis, some patients may develop deformities in the hand joints, commonly including ulnar deviation, swan neck deformities, or boutonniere deformities. Some patients may experience significant stiffness leading to limited mobility of the hand joints.

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Written by Li Jing
Rheumatology
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Does rheumatoid arthritis hurt?

Firstly, rheumatoid arthritis belongs to autoimmune diseases and is a chronic condition. The main symptoms include symmetric pain in multiple joints across the body, accompanied by morning stiffness, which is why joint pain occurs and is the most common symptom. The onset is slow for most people, but some experience an acute onset, with joint mobility issues appearing within a few weeks or days. Therefore, this disease cannot be cured; it can only be managed with medications to control symptoms, delay the deformity of joints, reduce disability rates, and enhance the quality of life, which are the objectives of comprehensive treatment. It is important to avoid exposure to cold and fatigue in daily life, avoid contact with cold water, keep warm, also avoid raw and cold foods, spicy and irritating foods, and eat more light, easy-to-digest, and high-protein foods to boost the immune system.