What medicine is used for rheumatoid arthritis?

Written by Li Jing
Rheumatology
Updated on September 19, 2024
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First, rheumatoid arthritis is an autoimmune disease and a chronic condition that cannot be cured. The primary goal of treatment is to alleviate symptoms, delay complications, improve quality of life, and reduce disability through conventional drug therapies. Treatment methods include general treatment and medication. General treatment consists of functional exercise and lifestyle considerations, such as avoiding cold water and raw, cold foods, and emphasizing the importance of exercise. Additionally, the first-line drug treatments include nonsteroidal anti-inflammatory drugs and disease-modifying antirheumatic drugs (DMARDs), with traditional DMARDs being the current preferred and anchor treatment option.

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Written by Liu Li Ning
Rheumatology
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How is rheumatoid arthritis treated?

The treatment of rheumatoid arthritis is divided into general treatment and pharmacological treatment. General treatment mainly involves avoiding overexertion, having a light diet, and not staying up late. Pharmacological treatment is mainly divided into treatment during the acute flare-up phase and the remission phase. The acute phase focuses on anti-inflammatory and pain relief treatments, with non-steroidal anti-inflammatory drugs (NSAIDs) as the first choice, such as etoricoxib, meloxicam, or celecoxib. If the effect is not satisfactory, low-dose corticosteroid therapy may be combined. In the remission phase, slow-acting anti-rheumatic drugs are preferred, such as methotrexate, leflunomide, or sulfasalazine. If the slow-acting anti-rheumatic drugs are not effective, biologic agents such as tumor necrosis factor antagonists or JAK inhibitors may be combined.

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Written by Li Jing
Rheumatology
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Rheumatoid arthritis symptoms

Rheumatoid arthritis is categorized as an autoimmune disease and is a chronic autoimmune condition that is destructive to joints. It is primarily characterized by symmetric polyarthritis, with clinical manifestations varying significantly among individuals. Most cases begin gradually, initially presenting with symmetrical pain and swelling in the wrists. This often accompanies morning stiffness, fatigue, low-grade fever, muscle pain, or weight loss. In a minority of cases, the onset is more abrupt, with typical clinical manifestations appearing within a few days, including joint dysfunction, morning stiffness, and joint pain and swelling. Joint deformity is a later manifestation of the disease, indicating that the disease was not well-controlled, leading to joint damage.

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Written by Yang Ya Meng
Rheumatology
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The difference between osteoarthritis and rheumatoid arthritis.

Osteoarthritis is primarily a degenerative joint disease, most commonly occurring in weight-bearing joints and the distal joints of both hands. Therefore, if there is pain in the distal joints of the hands or in joints like the knee, it may be osteoarthritis. Rheumatoid arthritis mainly affects the metacarpophalangeal joints, proximal interphalangeal joints, and both wrists. It is also important to distinguish that in patients with osteoarthritis, inflammation indicators such as sedimentation rate, C-reactive protein, and endocrine factors are usually normal. However, in patients with rheumatoid arthritis, these indicators, including sedimentation rate, C-reactive protein, and rheumatoid factor, are abnormally elevated.

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Written by Yang Ya Meng
Rheumatology
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Rheumatoid Arthritis Diagnostic Criteria

The diagnostic criteria for rheumatoid arthritis include the following aspects: The first is symmetrical joint pain, primarily characterized by tenderness and swelling in the metacarpophalangeal joints, proximal interphalangeal joints, and both wrists. Secondly, it also includes abnormalities in inflammation markers, which comprise erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), along with abnormalities in certain antibodies, mainly rheumatoid factor, CCP antibodies, and AKA antibodies. If the above symptoms are present, and these inflammation markers and antibodies are found to be abnormal upon blood testing, a diagnosis of rheumatoid arthritis can be made.

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Written by Li Jie
Orthopedics
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How to treat rheumatoid arthritis?

Rheumatoid arthritis-induced joint pain has several distinct characteristics: The first is that it initially affects the small joints of the limbs, typically involving the hands, feet, wrists, and ankles, before spreading to larger joints. It rarely starts in the large joints first. Secondly, the onset is generally symmetrical, meaning it seldom affects just a single limb or joint. Typically, if the disease manifests, it affects both limbs simultaneously. Another characteristic is significant morning stiffness, meaning a feeling of stiffness upon waking up in the morning. Generally, by combining auxiliary tests such as blood tests and imaging, a clear diagnosis of rheumatoid arthritis can be made. Once diagnosed, it is advised that patients seek treatment at a reputable hospital in the rheumatology and immunology department or orthopedics, targeting specific treatments and avoiding unlicensed practitioners. Common rheumatoid arthritis treatment plans start with medications to alleviate symptoms, using immunosuppressants. In severe cases, a small, short-term dose of steroids may be used. Additionally, symptomatic treatment may include topical applications of ointments to improve blood circulation, reduce swelling, and alleviate pain. Patients can also take non-steroidal anti-inflammatory drugs orally to relieve symptoms. Furthermore, traditional Chinese medicine is also a very effective method, and patients can take specific herbal medicines as symptomatic treatment for rheumatic joint pain, which are also very effective. (Please follow a professional physician's guidance when using medications and do not medicate blindly.)