How to relieve ankylosing spondylitis

Written by Yang Ya Meng
Rheumatology
Updated on April 09, 2025
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Methods to alleviate ankylosing spondylitis are as follows:

First, in terms of lifestyle: during the remission phase of ankylosing spondylitis, it is necessary to persist in long-term functional exercises to keep the spine from adhering and becoming rigid.

The second and most important aspect is the long-term use of medication. The medications used to treat ankylosing spondylitis mainly include the following categories: The first category is non-steroidal anti-inflammatory drugs, commonly used ones include diclofenac sodium sustained-release tablets, celecoxib capsules, etc.; the second category includes disease-controlling medications such as sulfasalazine, thalidomide, methotrexate, and even leflunomide. Currently, the most effective medications for treating ankylosing spondylitis are biologics. However, before using biologics, it is essential to strictly rule out diseases such as hepatitis, tuberculosis, and tumors.

(Medications should be used under the guidance of a doctor based on specific conditions.)

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Written by Yang Ya Meng
Rheumatology
1min 8sec home-news-image

What medicine is used for ankylosing spondylitis?

The medication for ankylosing spondylitis mainly involves three aspects. The first is non-steroidal pain-relief medications, commonly including drugs like sustained-release diclofenac sodium tablets. The second involves drugs that control the condition, commonly using medications like sulfasalazine and thalidomide. The third, which is currently the most effective, involves treatment with biologics. Common biologics include tumor necrosis factor inhibitors. However, before using biologics, it is crucial to rigorously rule out complications such as hepatitis, tuberculosis, and tumors. Only after excluding these conditions should one consider using biologics. Patients with ankylosing spondylitis should also pay attention to appropriate functional exercises in daily life to prevent the stiffening of spinal joints. (Medications should be used under the guidance of a doctor, based on the specific situation.)

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Written by Li Jing
Rheumatology
1min 14sec home-news-image

Ankylosing Spondylitis Test Items

Ankylosing spondylitis is a systemic disease of unknown cause, primarily characterized by chronic inflammation of the axial joints. It mainly affects the sacroiliac joints and leads to bony ankylosis, predominantly occurring in males, especially young males. The disease has a significant familial genetic tendency. The main symptoms are pain or discomfort in the lower back and back, typically occurring at night, accompanied by difficulty turning over. Stiffness is evident in the morning or after sitting for a long time, but symptoms may alleviate after physical activity. In young and middle-aged males showing these symptoms, ankylosing spondylitis should be suspected first. The main diagnostic methods include blood tests for HLA-B27, and imaging such as CT or MRI of the sacroiliac joints to detect any sacroiliitis. Diagnosis primarily relies on the combination of symptoms, HLA-B27 results, and sacroiliac joint CT findings.

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Written by Li Jing
Rheumatology
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Does ankylosing spondylitis have a genetic component?

Ankylosing spondylitis is an autoimmune disease primarily affecting the axial joints. The onset is determined by both genetic and environmental factors, leading to the disease. This means that the disease exhibits a significant familial aggregation and genetic predisposition. If the parents have it, the incidence in their children is much higher than in others. However, it is definitely not a genetic disease; it just has familial clustering and genetic tendencies. If symptoms like stiffness in the neck or pain in the lower back intensify when at rest and decrease after activity, it is essential to use CT or MRI scans and test for HLA-B27 to check for damage or narrowing in the sacroiliac joints. Early diagnosis and early treatment are crucial to improve the prognosis of the condition.

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Written by Na Hong Wei
Orthopedics
1min 34sec home-news-image

What is Ankylosing Spondylitis?

Ankylosing Spondylitis (AS), where "A" stands for fusion and "S" for spine, refers to the condition where the bones and joints of the spine are fused together. Ankylosing Spondylitis is defined as a chronic inflammatory disease primarily affecting the axial skeleton and major limb joints. It is characterized by fibrosis and ossification of the intervertebral discs’ annulus fibrosus and nearby connective tissues, as well as ankylosis (stiffening) of the joints. It presents as a sterile inflammation occurring in the spine. However, it is not solely limited to the spine as it also involves the axial bones and major limb joints. The pathological hallmark of the disease includes inflammation mainly at the sacroiliac joints and points of attachment to the spine, leading to joint stiffness and calcification of the spinal ligaments and joints. The disease progression begins at the sacroiliac joint, spreading upwards through the entirety of the spine, and eventually stops at the cervical vertebrae. Symptoms start with pain in the early stages, followed by restricted mobility in the intermediate phase, and ultimately leading to deformities of the abdomen and back, culminating in severe hunchback. The exact cause of Ankylosing Spondylitis remains unclear, with various theories proposed but none universally accepted. Additionally, it is categorized under rheumatologic and immunologic disorders.

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Written by Sun Shu Jian
Orthopedics
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Early symptoms of ankylosing spondylitis

The early symptoms of ankylosing spondylitis mainly include insidious onset of pain and discomfort in the back and hip joints. The pain is often intermittent and worse at night. Patients frequently wake up at night due to back pain, which can be alleviated by slight movement. Therefore, when patients experience unexplained back and hip joint pain, it is necessary to determine whether ankylosing spondylitis could be a possibility. In the early stages, a sacroiliac joint CT scan and hematological examination can be performed to confirm the diagnosis. Once diagnosed, prompt standardized treatment is necessary. Generally, this can control synovial inflammation and pain, prevent deformities of the spine and joints, and help patients return to normal life and work.