Does type 2 diabetes have a genetic component?

Written by Tang Zhuo
Endocrinology
Updated on March 29, 2025
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Diabetes has a high prevalence worldwide, especially type 2 diabetes, which accounts for over 90% of all cases. The pathogenesis of type 2 diabetes is very complex, including genetic susceptibility, as well as environmental factors, insulin resistance, and defects in the function of pancreatic beta cells. Thus, environmental factors are one of the influencing factors in the incidence of type 2 diabetes. There is evidence showing a familial clustering tendency among patients, but genetic factors are not the sole cause of type 2 diabetes; environmental factors also play a role. With changes in diet and lifestyle in recent years, the prevalence of type 2 diabetes has noticeably increased. Even with similar genetic backgrounds, the risk of developing type 2 diabetes varies among populations living in different areas. Therefore, diabetes can be considered a complex disease, where individuals with a genetic predisposition to diabetes, under the influence of adverse environmental conditions, can also develop elevated blood sugar levels and consequently diabetes.

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Prevention of Gestational Diabetes

The prevention of gestational diabetes mainly focuses on diet and exercise. First, weigh yourself every morning to monitor weight changes during pregnancy, as excessive weight gain can increase the risk of gestational diabetes. Second, maintain a healthy and balanced diet that is low in fat and calories, and high in fiber and protein, avoiding excessive consumption of high-sugar foods. Third, regularly engage in exercises suitable for pregnancy. Fourth, keep a regular routine. Finally, closely monitor the fetus.

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How to reduce sugar in a diabetic diet?

Dietary control is the most important method of treatment for diabetes. If dietary control is improper, all hypoglycemic drugs, including insulin, will not be very effective, and the focus of dietary management in diabetes is to control the intake of carbohydrates. Our Chinese diet is primarily based on carbohydrates like rice. Mainly, we control the amount of rice consumed, with each meal (lunch and dinner) consisting of about 100 to 200 grams of rice. This is complemented by plenty of vegetables and a certain amount of lean meat to enhance satiety. By controlling the intake of carbohydrates in our daily lives, blood sugar levels can drop significantly.

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Care for diabetic foot

The first fundamental step is monitoring blood glucose; good control of blood glucose levels is essential for the effective management of diabetic foot problems. Secondly, attention must be paid to the protection of the wound. It's crucial to keep the wound clean, perform regular cleaning and disinfection, and when necessary, debride necrotic tissue thoroughly. For instance, if there is a sinus tract or deep ulceration, it is essential to open the wound and ensure drainage, removing all necrotic tissue inside. Thirdly, footwear choice is critical for patients with diabetic foot; it is important to wear shoes that are loose fitting, moderately soft yet firm, and capable of evenly distributing pressure across the footbed. There are shoes specially designed for those with diabetic foot, and these can be custom-made. Other considerations include maintaining good blood pressure control and ensuring adequate nutrition to support wound healing, including sufficient protein intake, which plays a vital role in promoting wound repair.

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Diabetes dietary taboo fruits

Many patients have a misconception after being diagnosed with diabetes; they think that fruits are sweet and they should avoid all fruits. This statement is half right—fruits are indeed sweet, but not all fruits are off-limits. Diabetes patients can still consume fruits, provided that they pay attention to the quantity and type of fruit they eat. First, let’s discuss the fruits that should not be eaten by diabetic patients, which are those high in simple sugars. Consuming these fruits can cause a rapid spike in blood sugar levels. Examples include dates, whether dry or fresh, longans, whether dry or fresh, lychees, whether dry or fresh, and bananas, which all have very high sugar content. These fruits are not recommended for diabetic patients; on the other hand, fruits like kiwis, cherries, kumquats, and grapefruits are generally suggested as suitable for diabetic patients.

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Gestational diabetes symptoms

During pregnancy, there are two scenarios concerning diabetes: one is where diabetes is diagnosed before pregnancy, referred to as pregestational diabetes combined with pregnancy. The other scenario is where the sugar metabolism is normal before pregnancy, or there is an underlying reduced glucose tolerance, and diabetes appears or is diagnosed during pregnancy, also known as gestational diabetes. Over 80% of diabetic pregnant women have gestational diabetes. Typically, gestational diabetes doesn't show clear symptoms of the classic "three polys and one less" - excessive drinking, eating, urination, and weight loss. Some women with gestational diabetes may experience itching of the vulva, caused by repeated infections with Candida albicans. Additionally, gestational diabetes may lead to conditions like fetal macrosomia and polyhydramnios during pregnancy, and pregnant women with gestational diabetes are more prone to infections.