What are the symptoms of late-stage pancreatic cancer?

Written by Liu Liang
Oncology
Updated on September 17, 2024
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Some common symptoms of advanced pancreatic cancer include abdominal pain and upper abdominal pain, and it is even possible to feel an obvious lump in the abdomen. Jaundice is also a common symptom. Some patients may also experience nausea, vomiting, abdominal bloating, and abdominal pain, even ascites, which is a sensation of abdominal fullness. They are unable to eat, and eating can worsen the bloating. These clinical manifestations are accompanied by clearly noticeable abdominal pain. There are also symptoms associated with distant organ metastasis, such as when metastasis to the lungs can cause shortness of breath, coughing, and even hemoptysis. Some patients may experience extensive abdominal metastasis, which can even lead to intestinal obstruction and other clinical presentations.

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Written by Yan Chun
Oncology
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Early symptoms and signs of pancreatic cancer

Pancreatic cancer is a malignant tumor of the digestive system and does not have a high clinical incidence rate. Early symptoms of pancreatic cancer are not typical; some patients experience abdominal pain, primarily a persistent episodic pain that may radiate to the shoulder and back. Additionally, early-stage pancreatic head cancer patients may exhibit jaundice, often caused by obstructive jaundice due to tumor compression. Besides this, patients may also have clay-colored stools or urine the color of strong tea. Beyond these symptoms, early-stage patients exhibit no other signs. When typical clinical manifestations occur, they are generally indicative of mid to late-stage pancreatic cancer. Precursors to pancreatic cancer include persistent hidden pain in the shoulder or a stiff pain in the back. This continuous pain, often caused by the invasion of the abdominal nervous plexus, results in radiating pain.

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Written by Liu Liang
Oncology
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What should I do if I can't stop vomiting due to pancreatic cancer?

Firstly, we need to ascertain the cause of the vomiting and can provide gastric protection and antiemetic treatment accordingly. If the vomiting is due to biliary obstruction caused by pancreatic cancer, resulting in severe jaundice and intense vomiting, in such cases, we can also place a stent surgically to drain the bile. The jaundice might be relieved afterwards, and accordingly, the vomiting symptoms might also be alleviated. Another aspect is, if the vomiting is caused by the tumor itself due to pancreatic cancer, we need to employ chemotherapy or some targeted or antiangiogenic treatments to control the tumor itself, and only then might the symptoms of vomiting be relieved.

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Written by Liu Liang
Oncology
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How to screen for pancreatic cancer

Pancreatic cancer is a common malignant tumor of the digestive tract. Due to its high malignancy and rapid progression, it severely affects human health. So how should pancreatic cancer patients be screened? Generally, abdominal ultrasound examination is the primary screening method. Another method is the examination of tumor markers, mainly carcinoembryonic antigen (CEA) and CA19-9. CA19-9 is a tumor marker with relatively high specificity and sensitivity for the diagnosis of pancreatic cancer. Therefore, during physical examinations, we can draw blood to check these tumor markers. If there is a significant increase in CA19-9 or CEA, further examinations of the pancreas, such as ultrasound or CT of the pancreas, should be conducted to further investigate whether there is a tumor in the pancreas.

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Written by Liu Liang
Oncology
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How is pancreatic cancer diagnosed?

The most common symptoms of pancreatic cancer are pain in the upper abdomen and jaundice. During physical examination, a mass in the upper abdomen can be felt, which is a common symptom. When these symptoms appear, further abdominal ultrasound or CT scans should be performed, as these two are the most commonly used imaging methods for diagnosing pancreatic cancer. Additionally, pancreatic MRI or PET-CT can also help enhance the diagnostic accuracy for pancreatic cancer. MRCP and ERCP are also used to assess the bile ducts and to evaluate the feasibility of surgery. Blood tests for pancreatic cancer-related tumor markers, such as carcinoembryonic antigen (CEA) and CA19-9, are commonly performed, with CA19-9 being particularly sensitive and specific for the diagnosis of pancreatic cancer.

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Written by Sun Ming Yue
Medical Oncology
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Classification of the Malignancy of Pancreatic Cancer

Pancreatic cancer can also be described as a malignant tumor occurring in the pancreas, generally with a high malignancy level, resulting in a higher probability of patient death. To understand the classification of pancreatic cancer, it can be categorized based on the location of occurrence within the pancreas and the pathological type. Based on the location of occurrence, pancreatic cancer can generally be divided into cancers of the pancreatic head, body, tail, and entire pancreas. According to the pathological types of pancreatic cancer, it can be classified into ductal adenocarcinoma, and also some special types of ductal-origin cancers, which generally include pleomorphic carcinoma, mucinous carcinoma, adenosquamous carcinoma, mucinous cystadenocarcinoma, and signet ring cell carcinoma, among others.