What should be done if pancreatic cancer has not metastasized?

Written by Liu Liang
Oncology
Updated on September 25, 2024
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If pancreatic cancer has not metastasized, then it might be in an early stage. In this situation, consultation with a hepatobiliary surgeon is necessary for the surgeon to assess whether curative surgery can be performed. If the surgeon determines that curative surgery is feasible, this should be the preferred treatment method. Post-operatively, based on whether there are symptoms of recurrence or metastasis, such as vascular tumor thrombi or lymph node metastases, decisions concerning the necessity for adjuvant radiotherapy or chemotherapy should be made based on these high-risk factors for recurrence and metastasis.

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What are the abnormalities in blood indicators for pancreatic cancer?

Blood markers for pancreatic cancer often show multiple abnormalities. Pancreatic cancer itself can lead to an increase in related tumor markers. The two most common markers are carcinoembryonic antigen and carbohydrate antigen 19-9, especially carbohydrate antigen 19-9, which has a certain specificity. If pancreatic cancer progresses further, leading to compression of the biliary system, corresponding jaundice indicators can increase. This includes an increase in total bilirubin and direct bilirubin, as well as alkaline phosphatase and gamma-GTP. The most common metastasis site for pancreatic cancer is the liver, and after liver metastasis occurs, corresponding liver transaminases can increase.

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What does pancreatic cancer ascites mean?

When pancreatic cancer causes ascites, particularly a large amount, we can collect the ascites to search for cancer cells. This generally indicates peritoneal metastasis, or metastasis above the liver which can also cause substantial ascites. In such cases, it typically signifies that the disease has progressed to a late stage, classified as stage IV. Patients in this category are unable to undergo surgery and their treatment primarily involves chemotherapy. If the patient's overall condition is good, chemotherapy can be chosen. If the patient's condition is relatively poor, targeted therapy or oral anti-angiogenesis medications may be selected to control the pancreatic cancer and manage the tumor. If the patient's condition is particularly poor, the approach involves placing a peritoneal drainage tube to remove the ascites and providing the best possible symptomatic supportive care.

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Can acute pancreatitis turn into pancreatic cancer?

Acute pancreatitis and pancreatic cancer are two diseases that occur in the same organ, the pancreas. However, acute pancreatitis is entirely an inflammatory change, often caused by gallstones, alcohol consumption, binge eating, and hyperlipidemia, with some cases being idiopathic. Pancreatic cancer, on the other hand, is a tumorous lesion and is a malignant tumor that generally requires surgery. Many pancreatic cancer patients are already in the advanced stages when discovered, making the surgery difficult to perform. The prognosis for patients is also completely different. After the onset of acute pancreatitis and treatment, the pancreas recovers, the inflammation subsides, and it does not affect a person's lifespan. However, if pancreatic cancer is clearly diagnosed, the lifespan oftentimes does not extend beyond a few years.

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How is pancreatic cancer diagnosed?

The most common symptoms of pancreatic cancer are pain in the upper abdomen and jaundice. During physical examination, a mass in the upper abdomen can be felt, which is a common symptom. When these symptoms appear, further abdominal ultrasound or CT scans should be performed, as these two are the most commonly used imaging methods for diagnosing pancreatic cancer. Additionally, pancreatic MRI or PET-CT can also help enhance the diagnostic accuracy for pancreatic cancer. MRCP and ERCP are also used to assess the bile ducts and to evaluate the feasibility of surgery. Blood tests for pancreatic cancer-related tumor markers, such as carcinoembryonic antigen (CEA) and CA19-9, are commonly performed, with CA19-9 being particularly sensitive and specific for the diagnosis of pancreatic cancer.

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What are the symptoms of pancreatic cancer?

The clinical manifestations of pancreatic cancer mainly depend on the location of the cancer, the stage of the disease, whether there is metastasis, and the involvement of adjacent organs. The clinical characteristics include a short disease course, rapid progression, and swift deterioration. The most common symptom is upper abdominal distension and discomfort, pain, though not all patients experience tenderness; if tenderness is present, it aligns with the area of pain felt. Pain is a primary symptom of pancreatic cancer, present whether the cancer is located in the head or the body/tail of the pancreas. Jaundice is a main symptom of cancer in the head of the pancreas, and patients often exhibit more severe gastrointestinal symptoms, most commonly loss of appetite, followed by nausea and vomiting. There might also be diarrhea or constipation, even melena. Diarrhea is often steatorrhea. In the early stages of pancreatic cancer, common symptoms include weight loss and fatigue.